Virus-Like Particles (VLPS) - Applications In Veterinary Medicine
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Date
2010-09
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Abstract
Vaccines against viral disease have traditionally relied
on attenuated virus strains or inactivation of infectious
virus. Subunit vaccines based on recombinant proteins
can suffer from poor immunogenicity owing to incorrect
folding of the target protein or poor presentation to the
immune system. A specific class of viral subunit vaccine
that mimics the overall structure of virus particles and
thus preserves the native antigenic conformation of the
immunogenic proteins. are called virus-like particles
(VLPs) which have been produced for a wide range of
taxonomically and structurally distinct viruses, and have
unique advantages in terms of safety and immunogenlcity
over previous approaches.
Description
TNV_LL_Sep2010_5