Synthesis of surface modified silver sulfide nanoparticles as antifungal agents
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Date
2019
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Punjab Agricultural University, Ludhiana
Abstract
Nanoparticles have great potential in the fields of biomedicine, building materials,
environmental protection, antibacterial and antifungal agents. Silver sulfide nanoparticles
(Ag2S NPs) have been synthesized for their applications in various fields including
photoconductors, photovoltaic cells, solar selective coatings and infrared detectors, but have
less reporting as bio-compatible material or in in vitro or in vivo applications. Silver sulfide
has been hypothesized as less toxic form in nature as metal nanoparticles of soft nature get their
ultimate fate by sulfidation as their natural pathway of detoxification. In this study we synthesized
silver sulfide nanoforms by approaching sonochemical method. Various sulfide ion sources
and silver nitrate were used as initial components for the synthesis of silver sulfide
nanoparticles (Ag2S NPs). All the synthesized samples were tested for their preliminary in
vitro antifungal activity against Ustilago hordei, Uromyces viciafabia, Fusarium moniliforme
and Bipolaris oryzae . Ag2S-4 NPs synthesized from sodium sulfide showed better antifungal
potential in comparsion to silver nanoparticles (Ag NPs) and commercially used standard
fungicides. The Ag2S-4 NPs sample was further coated with chitosan to get chitosan
decorated silver sulfide nanoparticles to evaluate the antifungal potential of this conjugate in
comparison to Ag2S NPs.
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