CLINICO-THERAPEUTIC STUDIES ON CANINE DIABETES MELLITUS.
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Date
2019-07-23
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CSKHPKV, Palampur
Abstract
The study was conducted on 12 diabetic dogs presented at Teaching Veterinary Clinical Complex, CSKHPKV, Palampur (H.P.) between February 2018 and March 2019. On the basis of history, clinical examination and laboratory findings, dogs affected with diabetes were subjected to haemato-biochemical examinations. The overall incidence of the disease was 0.99% (12/1212) in the cases presented to College Veterinary Clinics. Maximum no. of cases (7/12) were recorded in old dogs (>5 years) and in winter season (8/12). The prominent clinical signs observed in diabetic dogs were polydipsia, polyuria, polyphagia, weight loss and lethargy. The mean fasting blood glucose (FBG) in diabetic dogs at the time of diagnosis was 403.08±31.99 mg/dl. Out of 12 dogs, 8 were having blood glucose level above 350 mg/dl and 4 dogs were having fasting blood glucose level below 350 mg/dl. The mean activities of aspartate amino transferase, alanine transferase and alkaline phosphatase were markedly higher in diabetic dogs. The mean cholesterol, triglyceride, HDL-cholesterol, amylase and lipase level were markedly increased in diabetic dogs as compared to healthy dogs. Mineral and electrolyte profile revealed hypercalcaemia in diabetic dogs. Urine examination revealed hypersthenuria, glycosuria, variable ketonuria and leucocytes in urine samples of diabetic dogs. Anion gap was increased along with decreased blood pH and base excess which indicated metabolic acidosis. Oral hypoglycemics were not found to be effective in diabetes management in dogs. Insulin treatment was given @0.5 IU/kg bwt in dogs with mean fasting blood glucose >350 mg/dl (group I) and @0.25 IU/kg bwt in dogs with mean fasting blood glucose <350 mg/dl (group II) . Adjustments in the initial insulin dose were made in individual animals after generating serial blood glucose curve. Insulin treatment showed reduction in overt clinical signs of DM (polydipsia, polyuria, polyphagia, weight loss and lethargy), fall in FBG (63.32 percent in group I and 44.6 percent in group II) and improvement in haemato-biochemical parameters, at the end of 4 weeks treatment. Insulin therapy along with dietary modification showed marked therapeutic efficacy and improvement in overall quality of life in diabetic dogs.
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