EFFECT OF EDTA-TRIS ADJUVANT TO ANTIBIOTIC IN THE TREATMENT OF SUBCLINICAL ENDOMETRITIS IN BUFFALOES (Bubalus bubalis)
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Date
2022-06
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
The present investigation was conducted to evaluate the efficacy of
Ceftriaxone Tazobactam+Normal saline (Group I, n=10), Ceftriaxone
Tazobactam+EDTA-Tris (Group II, n=10) and EDTA-Tris (Group III, n=10)
in the treatment of subclinical endometritis in postpartum Graded
Murrah buffaloes. Buffaloes (n=65) presented with the history of repeat
breeding were screened by per rectal examination of the genital tract,
followed with assessment of cervico-vaginal mucus score, pH, uterine
discharge sample optical density and uterine discharge cytology.
Assessment of risk factors responsible for development of
endometritis revealed that, pluriparous buffaloes with poor body
condition score and maintained under poor housing hygiene had greater
risk for occurrence of endometritis.
Occurrence of symmetrical uterine horns with normal consistency
and thick and heavy uterine horns with extra curvature upon per rectal
examination were 72.31 (47/65) and 27.69 per cent (18/65), respectively.
The 47 endometritic buffaloes with normal, symmetrical uterine horns
were further screened for subclinical endometritis by assessment of
cervico-vaginal mucus score, which revealed that 38 (80.85%) buffaloes
showed clear mucus discharge of score 0. The pH of cervical mucus was moderately alkaline (7.5 to 8.0) in a high proportion of buffaloes (65.79%)
which were suspected of subclinical endometritis.
Occurrence of subclinical endometritis (cutoff >0.031 to 0.043) and
clinical endometritis (cutoff >0.043) based on optical density
measurement at 620 nm was 84.21 and 15.79 per cent, respectively. The
results showed that out of the 32 buffaloes evaluated for cytological
evidence 93.75% of buffaloes showed ≥5 to 10% and >10 to 15 % PMN
cells, while 2 (6.25%) showed >15 per cent PMN cells.
Ceftriaxone Tazobactam had shown highest sensitivity (65.0%)
upon ABST and it was selected for therapeutic trails by intrauterine route.
Biochemical cues revealed that variations in serum and uterine
discharges at post-treatment estrus as compared to pre-treatment estrus
values indicated that clearing of uterine infection after intrauterine
therapy.
Higher efficacy for Ceftriaxone Tazobactam+EDTA-Tris (80.00% Vs
87.50%) in terms of recovery and conception rates when compared to
treatment with EDTA-Tris (66.67% Vs 71.43%) and Ceftriaxone
Tazobactam+Normal saline (60.00 Vs 70.00%). In conclusion,
combination of Ceftriaxone Tazobactam with EDTA-Tris had improved the
clinical response and conception rate in buffaloes treated for subclinical
endometritis.
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