Clinical evaluation of ketamine, propofol or ketamine-propofol admixture (Ketofol) for induction of anaesthesia in diazepambutorphanol premedicated and isoflurane maintained dogs.
Loading...
Date
2014-07-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
CSKHPKV, Palampur
Abstract
The purpose of this study was to clinically evaluate ketamine, propofol or ketaminepropofol
for induction of anaesthesia in diazepam-butorphanol premedicated and maintained dogs.
Thirty clients owned dogs of either sex were randomly divided into three groups BDP
(Butorphanol-Diazepam-Propofol), BDK (Butorphanol-Diazepam-Ketamine) and BDKP
(Butorphanol-Diazepam-Ketofol). All dogs were premedicated with atropine sulphate @ 0.04
mg/kg b. wt subcutaneously followed fifteen minutes later with Butorphanol tartarate @ 0.2 mg/kg
b. wt IV. 5 minutes later Diazepam @ 0.5 mg/kg b. wt IV was administered followed by Propofol,
Ketamine or Ketofol “till effect” IV for induction of surgical anaesthesia as per group. After
induction, the animals were immediately transferred to isoflurane in oxygen. Observations recorded
in dogs included analgo-clinical observations, cardiovascular observations, haemodynamic
observations, anaesthetic response and dose, pulmonary responses and haemato-biochemical
observations at various time intervals.
The induction dose of propofol, ketamine or ketofol in BDP, BDK and BDKP group was
4.5±0.07 mg/kg, 5.0±0.23 mg/kg and 3.0±0.00 mg/kg respectively. Hypothermia was observed in
BDP and BDKP group. Increased heart rate and fall in diastolic arterial pressure and increase in
mean arterial pressure were observed in BDKP and BDK groups respectively after induction of
anaesthesia with no rhythmic disturbance. The CVP remained below normal range in BDK group.
SPO2 and ETCO2 remained in physiological limits in all the anaesthetic combinations. Significant
respiratory depression occurred in BDKP group after induction. Transient apnea was observed in
three animals in BDP group which was resolved after shifting of animal to 100% oxygen. Smoother
induction and transfer were achieved by all the combinations. Recoveries were smoother, and
excitement free in BDP group. Significant fall in Hb, PCV and TEC occurred in all the groups in
early phase. Biochemical parameters remained within normal limits in all the groups.
All the combinations used in present study and recommended for different types of
surgeries in dogs.
Description
Keywords
null