Estimation of humoral immune response in rabbits fed with Cucurbita maxima seeds
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Date
2013-07
Journal Title
Journal ISSN
Volume Title
Publisher
Veterinary World
Abstract
Aim : The objective of the study was to estimate the humoral immune response in rabbits treated with Cucurbita maxima seeds.
Materials and Methods: Thirty six male Newzealand White rabbits were divided into six groups (I, II, III, IV, V, VI) of six in each. Group I was the untreated control. Group II was treated with dexamethasone sodium (2 mg/Kg, i.m) for 7 days. Group III was treated with levamisole hydrochloride at 2.5 mg/kg (s.c) thrice a week. Group IV was treated with Cucurbita maxima seeds. Group V was treated with levamisole and dexamethasone and Group VI was treated with dexamethasone and Cucurbita maxima seeds. The seed was given @ 1000 mg/kg orally for 10 days. Antibody titre and serum immunoglobulin concentration were estimated along with haematology.
Results: Dexamethasone caused significant decreases in the antibody titre, immunoglobulin concentration where as Curcurbita maxima, Dexamethasone + Curcurbita maxima and dexamethasone + levamisole groups showed significant increase in these entities. There were no significant differences in RBC count, Haemoglobin contents among all the groups studied.
Conclusion: Results suggest that Cucurbita maxima seeds has the ability to stimulate humoral immune response in rabbits.
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Keywords
Cucurbita maxima, Dexamethasone, Levamisole Hcl, Rabbit