STUDIES ON THE INFLUENCE OF PENTOSAN POLYSULFATE SODIUM ON OSTEOARTHRITIS IN DOGS
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Date
2022
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The influence of pentosan polysulfate sodium for the treatment of
osteoarthritis in six dogs was studied. Hip joint was the most commonly affected joint,
followed by elbow joint and stifle joints. Most of the osteoarthritis cases were seen in
Labrador Retriever breed male dogs above five years of age. The drug pentosan
polysulfate sodium administered at the dose rate of 3 mg per kg body weight by
subcutaneous route at weekly intervals for four weeks was found to be effective and
best suited for the treatment of osteoarthritis in dogs. There were no significant
variations observed in physiological parameters like rectal temperature, respiratory
rate, and heart rate, haematological parameters like Hb, TEC, TLC, and DLC, and
biochemical parameters like serum creatinine and ALT. Weight bearing score, joint
motion score, pain score and lameness scores were highest before treatment, which was
significantly reduced from the seventh day till the 45th day after the treatment in all the
six dogs. There was significant improvement in weight bearing in all the six dogs after
the treatment. Radiographic evaluation after treatment showed significant improvement
in radiographic signs such as reduction in osteophytic changes, increase in the joint
space and improvement in remodeling of femoral head. The drug was also economically
feasible and easy to administer when compared to the daily oral medications.