SCREENING FOR ANTI-DIABETIC COMPOUND COROSOLIC ACID AND ANALYSIS OF BIOCHEMICAL CONSTITUENTS IN SELECTED MEDICINAL PLANTS
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Date
2017-11-20
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UNIVERSITY OF AGRICULTURAL SCIENCES GKVK, BENGALURU
Abstract
Present investigation of screening for anti-diabetic compound corosolic acid and
analysis of biochemical constituents were carried out in selected medicinal plants such as
Lagerstroemia speciosa (Banaba), Psidium guajava (Guava), Costus igneus, Costus
pictus (Spotted ginger, Insulin plant), Thymus vulgaris (Thyme), Catharantus roseus
(Periwinkle), Rosmarinus officinalis (Rosemary), Lavandula angustifolia (Lavender),
Mentha piperita (Peppermint) and Ocimum basilicum (Sweet basil). Corosolic acid also
referred as “Glucosol” reported to have active reduction in blood glucose level. Corosolic
acid is reported to have a vital role as anti-diabetic and anti-obesity agent. Selected
medicinal plants were screened for potential antidiabetic drug corosolic acid by HPLC
technique. In the present study methanolic leaf extracts of Rosmarinus officinalis (338.6
mg/100 g dw) shown to have higher amount of corosolic acid as compare to other
selected medicinal plants. Biochemical constituents viz., total protein, phenols, tannins,
flavonoids and antioxidants were analyzed. Rosmarinus officinalis shown to have higher
amount of flavonoids (2413.63 mg/ 100g fw) and antioxidants (837.1 mg/100g fw).
Catharantus roseus reports higher amount of total proteins (3.24 g/100 g fw) whereas
Ocimum basilicum recorded highest phenols (2485.36 mg/100 g fw). The leaves of
Lagerstroemia speciosa found to have higher tannin content (3927 μg/100 g fw). In the
present investigation corosolic acid was screened using HPLC, for the first time HPLC
reports the presence of corosolic acid in leaf samples of Rosmarinus officinalis. The
leaves of Rosmarinus officinalis can be good source of anti-diabetic compound ‘corosolic
acid’ and antioxidants.
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