Pharmacokinetics And Dosage Regimen Of Cefoperazone In Crossbred Cow Calves
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Date
2001
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Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana
Abstract
In the present study, pharmacokinetics, urinary excretion, in vitro plasma protein binding and dosage regimen of cefoperazone in crossbred cow calves weYe investigated. The cefoperazone was administered at the dose rate of 20 mg.kg-1 body weight. Cefoperazone in plasma and urine was estimated by microbiological assay technique using E. coli (ATCC 25922) as test organism. Plasma proten binding of drug was estimated by equilibrium dialysis technique. The peak plasma levels of cefoperazone following i.v. and i.m. adminstration were 117.4 ± 17.2 [tg.m1-1 at 1 min and 9.76 ± 0.25 prg.m1-1 at 45 min, respectively and drug could be detected in plasma upto 8 h. The pharmacokinetics of cefoperazone following i.v. and i.m. administration was calculated by three and one compartment open models, respectively. Non compartmental analysis of data was also done. The values of distribution half lives, 11/2 cci and ty, a2 were 0.08 ± 0.02 and 0.35 ± 0.03 h, respectively. The apparent volume of distribution, total body clearance and AUC of cefoperazone were 3.44 ± 1.00 L.kg-1, 594.0 ± 29.8 ml.kg-1.h-1 and 33.94± 1.871.1g.m1-1.h, respectively following i.v. administration,whereas these values were 3.44 ± 1.00 L.kg-1, 961.0 ± 296.0 ml.kg-1.h-1 and 16.28 ± 0.81 [ig.m1-1. H, respectively following i.m. administration of the drug. The elimination half lives of cefoperazone after i.v. and i.m. route we -r 3.94 ± 1.2 and 2.46 ± 0.11 h, respectively. Following i.m. administration, absorption rate constant and bioavailability were 5.43 ± 2.10 h-1 and 75.9 ± 18.5 per cent, respectively. The extent of plasma protein binding, 13; and Kr; of cefoperazone were found to be 29.8 ± 1.11 per cent, 1.91 x 10-8 ± 5.75 x 10-9 mole.g-1 and 7.77 x 10-7 ± 4.79 x 10-7 moles, respectively. On the basis of pharmacokinetic data, it is recommended that cefoperazone can be employed in the treatment of bacterial infections of crossbred cow calves at the dosage level of 15 mg.kg-1 followed by 12 mg.kg-1 at 8 h interval.