IN VITRO AND IN VIVO EFFICACY OF COW URINE DISTILLATE (CUD) FOR TREATMENT OF SUB CLINICAL ENDOMETRITIS IN CATTLE
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Date
2006
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Birsa Agricultural University, Kanke, Ranchi, Jharkhand
Abstract
Cow urine (gomutra) has many beneficial properties
particularly in the areas of agriculture and therapeutics. It has
also been observed during the scientific research that the urine
of Indian cows is highly effective and interestingly almost nil or
few medicinal properties are present in the urine of crossbred,
exotic cows, buffaloes etc. Recent researches have shown that
cow urine enhances the immune status of an individual through
activating the macrophages and augmenting their engulfment
power as well as bactericidal activity. Its major implications are
in agriculture biopesticides, electricity and kitchen fuels and as
therapy for many diseases.
The urine of cow contains all beneficial elements in it.
Hence it is natural and universal medicine that fulfills the
deficiency of elements and reduces the increased elements in
the body and it is the quality of urine which helps in curing even
the most incurable diseases. Cow urine contains 24 types of
salts and the medicines made from cow urine are used to cure
several diseases. Cow urine constitutes water 95%, urea 2.5%,
minerals, salts, hormones and enzymes 2.5%. It contains iron,
calcium, phosphorus, salts, carbonic acid, potash, nitrogen,
ammonia, manganese, sulphur, phosphates, potassium, urea,
uric acids, amino acids, enzymes, cytokines and lactose etc.
(Bhadauria; 2002).
Scientists/Clinicians are facing problems in modern allopathic
treatment due to the multiple drug resistance in microorganisms,
presence of antibiotic residues in food chain and/or associated
allergies and autoimmune disorders in man and animals. Immunity is
reducing drastically as a result of the environmental pollution, use of
agrochemicals in agriculture and presence of pesticides, heavy metal,
fungal toxins etc in the food chain. Deficient functioning of
macrophages leads to inefficacy of antibiotic drugs, development of
resistance in bacteria, recurrent infections, and/or decreased immune
status of an individual. As per WHO, the twentieth century wonder
drugs “antibiotics” will not remain useful and become almost
ineffective by the year 2020. In these circumstances one has to think
over the alternative therapeutic approaches to control the infections
(Garg and Chauhan, 2003 a; Chauhan, 2005). Due to paucity of
information on this aspect and the indiscriminate use of antibiotics to
treat the uterine infection has invariably resulted into emergence of
resistance among bacterial strains complicating the effectiveness of
therapeutic measure. Economically, the cow urine will be cheaper as
compared to other drugs available in the market. Keeping in view the
above facts, this study was planned with the following objectives:-
1. To investigate the efficacy of cow urine distillate
(CUD) against common genital tract microorganisms.
2. To compare the antimicrobial efficacy of CUD with
that of commonly used antibiotics.
3. To study the effect of CUD in sub -clinical cases of
endometritis in cattle.
The present study was carried out at Military dairy farm,
Namkom, Ranchi.A total of 60 cows were selected and grouped
into treatment (30) and control (30).All the animals were
diagnosed as sub clinical endometritis on the basis of history of
repeat breeding and isolation and identification of bacteria in
cervical mucus samples.A total of 68 bacterial isolates were
obtained from 60 cervical mucus samples.The different types of
bacteria identified were E. coli (26.47%), Streptococcus spp.
(23.52%), Staphylococcus spp. (20.58%), Bacillus spp.
(17.64%), Corynebacterium spp. (5.88%) & Pseudomonas
spp.(5.88%).Ciprofloxacin was found most effective (88.23%)
followed by Amikacin (82.35%), Gentamicin (79.41%),
Chloramphenicol (70.58%), Ampicillin (55.88), Oxytetracyclin
(52.94%) & Penicillin – G (35.29%).Neat CUD was found
effective against 54.41% of bacterial isolates followed by
diluted CUD (1:2) and (1:4) against 41.18% and 22.06%,
respectively. The overall conception rate was found to be
56.67% in animals treated with neat CUD. The overall
conception rate was found to be 23.33% in animals of control
group. There was significant difference in conception rate
between CUD treated and control groups.
Neat CUD may be used in animals affected with sub clinical
endometritis because it was most effective against bacterial isolates
among all the three concentrations and significantly higher conception
rate was recorded in the cows treated with CUD. Results obtained with
regard to sensitivity pattern were almost comparable with commonly
available antibiotics. Besides, it is economical as compared to
antibiotics and easily available.
Description
IN VITRO AND IN VIVO EFFICACY OF COW URINE DISTILLATE (CUD) FOR TREATMENT OF SUB CLINICAL ENDOMETRITIS IN CATTLE
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