Effect Of Paracetamol On Pharmacokinetics Of Ceftizoxime In Crossbred Cow Calves
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Date
2000
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Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana
Abstract
The present study was planned to determir e the effect of paracetamol on pharmacokinetics and dosage regimen of ceftizoxime in crossbred cow calves. Ceftizoxime and paracetamol were administered by intramuscular route at a dose rate of 10 and 50 mg.kg-1 body weight, respectively. Ceftizoxime in plasma was estimated by the microbiological assay technique using Escherichia coli (ATCC 25922) as the test organism, while paracetamol was estimated by spectrophotometric method. Following administration of ceftizoxime alone, drug followed one compartment open model. The minimum inhibitory concentration 1.0 j_tg.m1-1) was maintained from 1 min to 6 h after its administration. The values of absorption half-life, elimination half life, apparent volume of distribution (Vd(area)) and total body clearance were 0.23 ± 0.03 h, 1.44 ± 0.12 h, 0.58 L.kg-1 and 283.4 ± 28.1 ml.kg-1.11-1, respectively. Pharmacokinetics of ceftizoxime was also analysed by one compartment open model, when it was administered with paracetamol. The M1C was maintained from 1 min to 8 h. The values of absorption half life, elimination half life, Vd(area), and C18 were 0.12 ± 0.04 h, 2.78 ± 0.59 h, 0.58 ± 0.01 L.kg-1 and 164.3 ± 32.2 ml.kg-1.h-1, respectively, when ceftizoxime was administered with paracetamol. The t1,2Ka, tvg, Vd(area. and C1B of paracetamol were 0.31 ± 0.09 h, 2.27 ± 0.39 h, 1.35 ± 0.44 L.kgand 387.6 ± 51.14 ml.kg-1.h-1, respectively. On the basis of pharmacokinetic data, a satisfactory intramuscular dosage regimen for ceftizoxime alone would be 11.7 mg.kg-1 followed by 11.6 mg.kg-1 at 6 h ntervals. However, the dosage regimen for ceftizoxime was reduced to 7.5 ng.kg-1 followed by 6.1 mg.kg-1 at 6 h interval when it was given with paracetamol. On the basis of information gathered from the present study, it is concluded that the concomitant administration of paracetamol alters the pharmacokinetics and dosage regimen of ceftizoxime.