Clinicopathological studies of PPR (Peste des petits ruminants) in sheep and goats along with molecular characterization of the virus in Odisha

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dc.contributor.advisorPanda, Susen Kumar
dc.contributor.authorRath, Prasana Kumar
dc.contributor.otherPatra, Ramesh Chandra
dc.contributor.otherMishra, Umakanta
dc.contributor.otherSahoo, Gyan Ranjan
dc.contributor.otherSahoo, Pramod Kumar
dc.contributor.otherSenapati, Shanti Bhusan
dc.date.accessioned2022-01-21T11:22:53Z
dc.date.available2022-01-21T11:22:53Z
dc.date.issued2020
dc.descriptionTh-6071en_US
dc.description.abstractThere were total fourteen suspected outbreaks of PPR occurring in almost eight districts of Odisha comprising of 361 small ruminants. There was 49.65% mortality in goats and 36% mortality among sheep. There was highest occurrence of PPR among the age groups 6 -12 months (46.13%), females (80.49%), Ganjam breeds (45.51%) and in animals with poor body conditions (54.48%). There was a significant increase in Hb, TEC, PCV and TLC both in affected goats and sheep with nutrophillia and lymphopaenia. There was a significant increase in creatinine, urea, BUN, AST, ALT, K+ and Na+concentrations in PPR affected small ruminants. Prominent patho-anatomical changes were soiled hind quarters and tails, erosive & ulcerative lesions on oral mucosa, crusts on nose, matting of eyelids, pseudo membrane like deposits on tongue, frothy exudates as well as haemorrhages in trachea along with antero-ventral consolidation of lungs. There was desquamation of lingual papillae along with infiltration of inflammatory cells in papillary area of tongue, sinusoidal dilatation with congestion and hemorrhage associated with disruption of hepatic cords, presence of intracytoplasmic inclusions in hepatocytes, villous atrophy, depletion of spleenic pulp and congestion, congestion of inter alveolar septa with infiltration of macrophages, plasma cells with syncytia formation, I/n eosinophilic inclusions in alveolar macrophage of lungs as well as I/c eosinoiphillic inclusions in alveolar epithelial cells were important findings in affected animals in our study. The gene sequence information was submitted to the NCBI database with GenBank accession no. MG748708, MG748709, MG748710, MG748711. The current isolates were clustered to Asian lineage IV with a close relation to earlier reported Indian strains such as Delhi (KX033350.1) and Tamil Nadu (KT860065.1 and KT860064.1). The result revealed that the current isolate is 98.8 %-100% identical with previously reported Indian isolates. It has > 95% identity with lineage IV and 91% -94 % identities with lineage I, II and III. The overall divergence calculated for the current study was less than 10%. Lineage IV differs primarily at 13 amino acid positions compared to other lineages. There were four unique mutations (E297D, W333G, G461R, and E512G).en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810181133
dc.keywordsPPR (Peste des petits ruminants), sheep and goats, nutrophillia and lymphopaenia, hepatocytes, villous atrophy, Odishaen_US
dc.language.isoEnglishen_US
dc.pages188pen_US
dc.publisherDepartment of Veterinary Pathology, OUAT, Bhubaneswaren_US
dc.subVeterinary Pathologyen_US
dc.themePPR (Peste des petits ruminants), sheep and goats, nutrophillia and lymphopaenia, hepatocytes, villous atrophy, Odishaen_US
dc.these.typePh.Den_US
dc.titleClinicopathological studies of PPR (Peste des petits ruminants) in sheep and goats along with molecular characterization of the virus in Odishaen_US
dc.typeThesisen_US
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