Studies On Use Of Human Amniotic Membrane In Esophageal Surgery In Dogs
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Date
1993
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Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana
Abstract
Esophageal healing along esophagotomy site was
evaluated with amniotic membrane casing (5 dogs). Healing of
the experimentally created esophageal mucosal defects with
( 5 dogs) and without amniotic membrane graft (2 dogs) was
also evaluated. Interpositioning of the autogenous avascular
intestinal (ileum or colon) segment to bridge the smaller
cervical esophageal resections (5 dogs) was also carried
out. There was only one survivor (ileal graft) in this
group. Animals were fed via pharyngostomy tube for first 7
days, except the animals subjected to simple esophagotomy
and amniotic membrane casing which in turn were fed by oral
route from the very beginning. Intestinal segment necrosis
and leakage was observed in animals subjected to avascular
intestinal segment grafting in 4 out of 5 animals. No
leakage was observed in any animal in rest of the groups.
Ho feeding problem with any feed was observed except in
animals subjected to mucosal stripping without membrane
graft. Initial weight loss followed by a gain was a common
feature. Haximum wall scarring observed at 15th
postoperative daƧ PO solved appreciably by 30th POD due to
soaked and dry feed boluses.Amniotic membrane casing exerted buttress effect to the
esophagus at the incision line. It enhanced the
re_cpithelization of the esophageal mucosal defects with loss
scarring. The grafted autogenous avascular ileal segment had
both macroscopic and microscopic vasculature. Esophageal
epithelial regeneration over the heal segment lumen was in
the process. Normal microscopic structure of ileum was lost