Studies on Thyroid Profile in Dogs with Special Reference to Assessment of Canine TSH
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Date
2024-04-10
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MAFSU, Nagpur
Abstract
The present study was undertaken to establish data about canine TSH and
its association with Total triiodothyronine (TT3), Total thyroxine (TT4), and Free
thyroxine (fT4) in healthy dogs; and to study alteration in canine TSH, Total
triiodothyronine (TT3), Total thyroxine (TT4) and Free thyroxine (fT4) in suspected
cases of thyroid dysfunction, if any. The present study enrolled a total of 77 dogs,
with 67 healthy and 10 hypothyroid.
The canine-specific TSH ELISA kit was used to measure the serum
concentration of cTSH, while a RIA kit was used to measure the serum
concentration of Total triiodothyronine, Total thyroxine, and Free thyroxine. The
mean concentration of Total triiodothyronine (TT3), Total thyroxine (TT4), Free
thyroxine (fT4), and Thyroid stimulating hormone (cTSH) in healthy dogs were
0.85 ± 0.04 nmol/l, 20.81 ± 0.78 nmol/l, 12.59 ± 0.35 pmol/l and 2.03 ± 0.01 μIU/ml
respectively. In hypothyroid dogs, the mean concentration of Total triiodothyronine
(TT3), Total thyroxine (TT4), Free thyroxine (fT4), and Thyroid stimulating
hormone (cTSH) was 0.93 ± 0.07 nmol/l, 9.01 ± 0.69 nmol/l, 5.87 ± 0.82 pmol/l
and 2.16 ± 0.03 μIU/ml respectively. The study reported significant changes in the
concentration of TT4, fT4, and cTSH between healthy and hypothyroid dogs.
In the case of healthy dogs, the reference range (25th to 75th percentile) of
cTSH was 1.96 -2.11 μIU/ml while in the case of hypothyroid dogs, the reference
range (25th to 75th percentile) of cTSH was 2.09-2.22. Out of 10 hypothyroid dogs,
70% had a reference range above the healthy range, while 30% had a reference
range equal to the healthy range. The sensitivity (%) and specificity (%) of the
measurement of cTSH were 63 % and 72 % respectively. The study revealed
discrepancies in clinical findings, hematobiochemical results, and thyroid profiles
in both healthy and hypothyroid dogs.