ANTI-ATHEROSCLEROTIC EFFECT OF MIRABILIS JALAPA IN EXPERIMENTAL AORTIC ATHEROSCLEROSIS IN WISTAR RATS
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Date
2021
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Abstract
The present study was conducted to find out the effect of Mirabilis jalapa L. against experimentally induced aortic atherosclerosis in 54 Wistar rats for a period of 30 days.
Fifty four Wistar rats were divided into six groups and given the following treatments: control – normal diet (day 1 to day 30), HCD group – high cholesterol diet (day 1 to day 30), EEM group – 70 per cent ethanolic root extract of Mirabilis jalapa L. (day 8 to day 30), atorvastatin group – atorvastatin (day 8 to day 30), HCD + EEM group – HCD (day 1 to day 30) + EEM (day 8 to day 30) and HCD + atorvastatin – HCD (day 1 to day 30) + atorvastatin (day 8 to day 30) for 30 days and two sacrifices were conducted on 15th and 30th day.
The preliminary phytochemical analysis of 70 per cent ethanolic root extract of Mirabilis jalapa L. (EEM) showed the presence of reducing sugars, flavonoids, tannins, saponins, steroids, alkaloids, glycosides, phenols, terpenoids and xanthoproteins. Seventeen chemical constituents were identified by GC-MS analysis and five bioactive compounds were having antimicrobial, anti-inflammatory and anti-tumor activities. HPTLC quantification of EEM showed the presence of 1.35 per cent of trigonelline.
The HCD group showed highly significant (P<0.01) increase in weekly body weight in 3rd and 4th week and total weight gain in 30 days study whereas highly significant (P<0.01) reduction in 4th week body weight and total weight gain in HCD + EEM and HCD + atorvastatin groups in 30 days study. The HCD group showed highly significant (P<0.01) decrease in feed intake on 2nd week onwards in 15 and 30 days study.