Non Steroidal Anti-Inflammatory (NSAIDs) Drugs on Cardiopulmonary Functions During General Anaesthetic Protocol in Dogs
Loading...
Date
2019-05
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Veterinary Association, Chennai
Abstract
A clinical study was conducted in 24 dogs to
compare the cardiopulmonary and isoflurane
sparing effects on inclusion of meloxicam,
ketoprofen, tolfenamic acid and flunixin in
general anaesthetic protocol of dogs. Meloxicam,
ketoprofen, tolfenamic acid and flunixin were
administered @ 0.2, 2.0, 4.0 and 1.0 mg per kg
i.v.in group I, II, III and IV animals, respectively.
Midazolam was administered @ 0.3 mg per
kg i.v. to all the animals. General anaesthesia
was induced with propofol @ 6 mg/kg i.v. in all
the animals and maintained with isoflurane.
Ovariohysterectomy (OHE) was performed as
per the standard technique. The tidal volume
(VT), minute volume (VE), saturation of peripheral
oxygen (SpO2), mean arterial pressure (MAP)
and electrocardiography (ECG) were recorded.
Fraction of inspired-oxygen, end-tidal oxygen,
fraction of inspired-carbon dioxide, end-tidal
carbon dioxide, fraction of inspired-isoflurane
and end-tidal isoflurane concentration were
also recorded continuously during maintenance
of anaesthesia. The postoperative analgesic
efficacy of meloxicam and ketoprofen was found
superior than tolfenamic acid and flunixin. No
major alterations in cardiopulmonary functions
were noticed by the inclusion of NSAIDs in the
anaesthetic protocol of dogs. Meloxicam had a
significant isoflurane sparing effect than other
drugs.
Description
TNV_IVJ_May2019_96(05)_34-37
Keywords
Veterinary Science, Veterinary Surgery and Radiology