CARDIOPROTECTIVE POTENTIAL OF LATHYRUS SATIVUS AGAINST EXPERIMENTAL MYOCARDIAL INFARCTION DUE TO ISOPROTERENOL IN RATS
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Date
09-11-15
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PVNR TVU
Abstract
In the experimental study, 30 male and female Wistar rats were
randomly divided into five groups with six rats in each group. Group 1
served as control. Groups 2, 3, 4 and 5 received Isoproterenol (ISP) @ 80
mg/Kg B.wt in normal saline (2 ml) on 28th and 29th day to induce myocardial
infraction. Group 2 served as ISP toxic control. Groups 3, 4 and 5 were
treatment groups, Lathyrus sativus seed flour was incorporated in the feed
@ 30, 50 and 75%.
The present study revealed significant alterations in serobiochemical
parameters and antioxidant profile in ISP control as compared to control
group 1, and Lathyrus treated groups. Among the treated groups, Lathyrus
@ 30% revealed significant improvement when compared to the remaining
two groups (50 and 75%) in all the parameters. The histological studies of
heart revealed marked changes in ISP control group, while therapeutic
groups revealed lesser degenerative changes.
Use of Lathyrus countered the adverse effects of ISP induced
myocardial infraction to major extent suggesting its vasodilation and
inhibition of platelet aggregation and antioxidant potential owing to
replenishment of antioxidant defences and decreasing the ischemic injury
due to presence of phenols and homoarginine. Phenols are known for their
antiradical and antioxidant property, while homoarginine is the substrate
for NO production.