|dc.contributor.advisor||Jadhao, P. T.||-|
|dc.description.abstract||The study was undertaken to evaluate the efficacy of Symphytum
Officinale as a stimulating agent in the process of long bone fracture healing.
Twelve clinical cases of long bone fracture in dogs presented at Teaching
Veterinary Clinical Services Complex, Nagpur reported during February 2014 to
July 2014, were divided into two equal groups and subjected to the treatment as
per schedule In group I, immobilization of fractured bone were carried out by open
reduction and inernal fixation. In group II, in addition to immobilization of fractured
bone, the Symphytum Officinale homoeopathy drug was administered @ four
globules twice a day for days for 21 days postoperatively.
In the present investigation breed wise distribution of long bone fracture
revealed highest incidence 50 percent in non-descript, 25 percent in Labrador,
16.66 percent in German shepherd and 8.33 percent in Pomeranian breeds. The
present study indicated that percentage of incidences of long bone fractures were
more in non-descript dogs. Incidence of long bone fracture were highest among
younger dogs of 0 to 6 months age group .
The immobilization of long bone fracture of both the groups was done
depending on the type of fracture and fractured bone. Among different types of
fractured bone, internal fixation by intramedullary pinning/nailing was done in nine
cases of long bone fracture (75%) and intramedullary pinning along with cerclage
wiring in two cases of humerus fracture (16.66%), bone plating was done in one
case of fracture of radius ulna (8.33%).
The method adopted for the administration of the symphytum officinale
homoeopathy drug of 30 c potency for oral administration in the dogs with
fracture of long bones during the present study was found suitable and easy and
the quantity of globules administered was found satisfactory as an osteoinducer.
The common preoperative consideration viz., preparation of animal,
premedication and anaesthetic procedure was followed for four dogs each from
groups I and II and subjected to open reduction and internal fixation of femur
bone with intramedullary pin/nail. The two dogs one each with fracture of
humerus in group I and II were subjected to be open reduction and internal
fixation with intramedullary pinning coupled with cerclage wiring .
The open reduction and internal fixation of fractured humerus with
intramedullary pinning in addition with cerclage wiring in both the groups were
found satisfactory; however, the perfect alignment and reduction was not
observed radiographically in both the groups. The reduction in healing time of
humerus fracture was observed in group II as compared to group I. The process of fracture healing was assessed on the basis of clinical,
radiological, hematological and biochemical observations recorded at scheduled
The wound healing in dogs of group I and group II was observed for about
7 to 12 days by primary intention.
The animals of group II with long bone fracture required less time for
partial weight bearing 3.25 ± 0.25 postoperative days and complete weight
bearing 25.75 ± 2.17 postoperative days as compared to group I and reduction in
weight bearing was statistically significant.
Radiographs taken at schedule intervals showed accelerated fracture
healing with complete bridging of fragment, bony deposition along with periosteal
and medullary continuity across the fracture site on animals of treated group II
whereas radiographic union and periosteal bridging at fracture site were relatively
slow and incomplete in dogs of group I at schedule interval.
The animals of group I and group II revealed non-significant changes of
hematological values such as hemoglobin, total erythrocyte count, total leucocyte
count, differential leucocyte count which does not affect the bone healing
process. The serum alkaline phosphatase level revealed decreasing trend in both
the group I and II which was statistically significant.
The enhancement of rate of fracture healing and reduction in partial and
complete weight bearing in animals of group II could be understood to the
therapeutic efficacy of symphytum officinale homoeopathy drug of 30 c potency
@ four globules twice a day as an anti-inflammatory, analgesic and specific
osteoinductive property along with the proper open reduction and internal fixation
of fractured bone.||en_US|
|dc.title||Role of Symphytum Officinale As An Osteoinducer In Long Bone Fracture Repair In Canine||en_US|
|dc.theme||Role of Symphytum Officinale As An Osteoinducer In Long Bone Fracture Repair In Canine||en_US|