STUDIES ON THE EFFECT OF QUERCETIN ON DIABETIC WOUND AND HYPERTENSION IN RATS
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Date
2016
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Division of Veterinary Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences & Technology of Jammu
Abstract
The present study was designed to evaluate the ameliorative effect of quercetin on
streptozotocin-induced-diabetes, diabetic wound and DOCA salt induced hypertension in
Wistar rats. Rats of 150-200g body weight were divided into six groups of six animals
each and were subjected to various daily oral treatment regimes for 21 days to determine
the effect of quercetin on diabetic wound healing. For evaluating the effect of quercetin
on hypertension male Wistar rats were divided into four groups of six animals each and
were subjected to various daily oral treatment regimes for six weeks. Oral administration
of quercetin @100mg/kg B.W for 21 days in diabetic rats normalized the altered blood
glucose, TC, HDL, triglycerides, LDL, protein profile, plasma urea nitrogen, creatinine
and antioxidant biomarkers (MDA, SOD, CAT, GST, GPx). Topical application of
quercetin ointment (15%) on the excised wound in diabetic wistar rats was sufficient
enough to heal the wound area. Hypertension was induced in uninephrectomized wistar
rats by weekly twice subcutaneous injection of DOCA @25mg/kg B.W for six
consecutive weeks. Treating the hypertensive rats with quercetin @20 mg/kg B.W for six
weeks significantly reduced (P<0.05) the mean arterial pressure. Furthermore, the lipid
profile was improved along with other biochemical (plasma urea nitrogen, plasma
creatinine, SGOT, SGPT) and oxidative stress parameters (MDA, CAT, SOD, GST,
GPx). Therefore, it is concluded that quercetin @ 100mg/kg B.W has antidiabetic
potential. Wound healing property has been excellently produced by 15% topical
application alone and 15% topical application + 100mg/kg B.W orally. Quercetin @
20mg/kg B.W for six weeks in rats was sufficient enough to reduce DOCA-salt induced
hypertension.
Description
Ph.D Thesis
Keywords
ANTIDIABETIC, ANTIHYPERTENSIVE, WOUND HEALING, QUERCETIN