Studies on Metamizole, Cyproheptadine and Phenobarbitone Sodium Interaction in Rats

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Date
1982
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TANUVAS
Abstract
The above findings clearly indicate that analgesic effect of metamizole was reduced or nullified at the dose of 225 mg/kg body weight on simultaneous administration with cyproheptadine at the dose of 0.1 mg/kg body weight, and 72 hours after the administration of phenobarbitone sodium at the dose of 100 mg/kg body weight and cyproheptadine at the dose of 0.1 mg/kg body weight. Hence both in therapy and during surgery, the above drug interactions should be taken into consideration while administering metamizole as an analgesic.
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Keywords
Metamizole, Cyproheptadine, Phenobarbitone sodium, Rats
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