Biokinetics of Norfloxacin And Metronidazole in Goats
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Date
1992
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Birsa Agricultural University, Ranchi
Abstract
.The semi logarithmic plot of blood level time profile of MNZ obtained following single dose I/V administration € 20 mg/kg b.w. in febrile goats showed a biphasic decay suggesting "two compartment open model disposition Kinetics of MNZ in goats.
2. Evidence has been presented that MNZ when given I/V au a single dose è 20 mg/kg b.w. produced Coax (50.86 ± 0.63 8/ml) and Omin (1.35 ± 0.23 ug/ml) at 2 min and 4 h respectively and Other sustained upto 4 h of drug administration.
3. The Kinetic parameters determined evidenced that the meant 1/2 & value of MNZ was 1.034 0.071 h while the sean Cl value was 8.464 + 0.384 ml/kg/min which reflected relatively a faster rate of drug elimination; the mean Cl value was 6.810 + 0.280 ml/kg/ain reflec ting the biliary excretion of MNZ.
4. The mean Vd value was found to be 0.845 ± 0.980 L/kg indicating a wide distribution of MNZ in febrile goats; the other biokinetic parameters determined were 21 (3.118 + 1.557 -1), 12 (5.103 ± 1.257 h-¹) and X₂ (1.629 + 0.104 b¹) following I/V administration of NNZ 20 mg/kg b.w.