Evaluation of etomidate, propofol and their combination as induction agents in buffaloes undergoing diaphragmatic herniorrhaphy
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Date
2023-04
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LUVAS Hisar
Abstract
The study was conducted on eighteen buffaloes suffering from diaphragmatic hernia reported
to the department of veterinary surgery and radiology, Lala Lajpat Rai University of Veterinary and
Animal Sciences, Hisar. Animals were randomly divided into three groups having six animals each.
After pre-anaesthetic medication with atropine, xylazine and butorphanol each animal was restrained in
lateral recumbency. Propofol, etomidate, etomidate-propofol combination were used as induction agents
in group AXBPI, group AXBEI and group AXBEPI respectively and isoflurane was used for
maintenance of anaesthesia. Scores for premedication, induction, maintenance, sedation and analgesia
were found almost similar in all groups, while in terms of recovery and muscle relaxation group
AXBPI was found better than group AXBEI and group AXBEPI. There was no significant change
observed in any physiological parameter in any group except for respiratory rate in which depression in
respiratory rate seen just after giving induction agent which was comparatively more in group AXBPI.
For haemoglobin and total leucocyte count, there was no significant difference found in between as
well as within the groups. For packed cell volume, significant difference was found in between the
groups in all the groups. For total erythrocyte count, neutrophils, lymphocytes, monocytes and
eosinophils significant difference was found within the group only. There was no significant difference
found in between as well as within the groups for ALT, AST, BUN, creatinine, sodium and potassium.
Significant difference was present within the groups for serum chloride and albumin. For total serum
protiens, globulin and albumin:globulin ratio significant difference was present in between the groups
at different time intervals. The significant difference was noticed in between as well as within the
groups at different time intervals for serum cortisol and calcium. All the drugs combinations were
found safe and effective for buffaloes undergoing diaphragmatic herniorrhaphy but quality of
anaesthesia in terms of muscle relaxation and recovery was found better in propofol than etomidate and
etomiate-propofol admixture when used as induction agent.