Whole Blood Transfusion as an Adjunct Therapy in Bubaline Phosphorus Deficiency Haemoglobinuria
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Date
2021-01-21
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MAFSU, Nagpur
Abstract
Phosphorus deficiency haemoglobinuria is an important production disease of lactating and advanced pregnant buffaloes. The present study was conducted to evaluate whole blood transfusion as an adjunct therapy in bubaline phosphorus deficiency haemoglobinuria during January 2019 to February 2020. A total of 1917 buffaloes admitted to TVCC over a study period were examined. Total 33 buffaloes were confirmed for PDH with overall hospital prevalence of 1.72%. The disease was more common in 6-9-year-old (0.83%), early lactating (1.2%) buffaloes during winter and summer (36.36% each) season. The diagnosis was done on the basis of history of production and diet, clinical signs, and decreased phosphorus values. The important clinical signs of reddish to coffee coloured urination, straining while defaecation, decreased milk production, anaemia with papery white, pale, icteric pale conjunctival mucous membranes were observed in ailing buffaloes. Haematological analysis showed highly significant reduction in total erythrocyte count, haemoglobin, PCV and lymphocyte count while increase in neutrophil counts. Biochemical analysis revealed highly significant increase in values of BUN, creatinine and bilirubin while decrease in inorganic phosphorus. To evaluate whole blood transfusion as an adjunct therapy in PDH, 12 affected buffaloes suffering from severe haemolyticanaemia (Hb< 5 gm/dl) were randomly divided into two groups. Group I buffaloes treated with standard treatment protocol without blood transfusion showed complete recovery in 5 buffaloes (83.33%) while death in 1 due to severe anaemia. Group II buffaloes treated with 1050 ml whole blood along with standard treatment protocol showed complete clinical recovery in all 6 buffaloes (100%). Haematological analysis in both groups showed good improvement in total erythrocyte count, Hb and PCV in group II buffaloes compared to group I buffaloes. In conclusion, whole blood transfusion could be used as an adjunct therapeutic modality in bubaline phosphorus deficiency haemoglobinuria in addition to standard treatment.