Synthesis, characterization and biological applications of Schiff base transition metal complexes
Loading...
Date
2021-09
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
CCSHAU, Hisar
Abstract
Three Schiff base liagndscuminalidene-4-aminoantipyrine(CUMAP),anisalidine-4-aminoantipyrine(AAAP), pyridoxalidene-4-aminoantipyrine(PAAP) was synthesized by the reaction of 4-aminoantipyrine with cuminaldehyde, anisaldehyde and pyridxoal, respectively. Ferrous, ferric and chromic complexes of these Schiff base ligands were also synthesized by using conventional reflux method. All the synthesized compounds were characterized using various spectroscopic techniques like elemental analysis, molar conductance, FTIR, 1H NMR and UV-vis. The obtained data revealed that Schiff base ligands CUMAP and AAAP act as a neutral bidentate while PAAP act as a monobasic tridentate ligand. Distorted tetrahedral, trigonal bipyramidal and octahedral geometry was assigned to the compounds. All synthesized compounds were tested for their antibacterial activity against Bacillus cereus and Xanthomonas campestris. Antifungal activity against Candida albicans and Macrophominaphaseolina was also carried out using agar well diffusion method. It was found that the Schiff bases had a very little or no antimicrobial activity while their metal complexes showed significant antimicrobial activity. It was found that maximum Bacillus cereus growth was inhibited by the compounds 1f, 2d and 3f and maximum Xanthomonas campestris growth was inhibited by the compounds 1f, 2d and 2e. Compounds 1f, 2a and 3f showed the maximum inhibitionagainstCandida albicans growth while compounds 1a, 2d, 3c and 3e showed maximum inhibition against Macrophominaphaseolinagrowth. In urease inhibitory activity it was found that the metal complexes have many times better activity than the Schiff bases. Compounds 2c, 3c and 3e showed the best inhibition against the urease enzyme.