ROMIFIDINE DEXMEDETOMIDINE AND XYLAZINE SEDATION WITH KETAMINE ISOFLURANE ANAESTHESIA FOR SURGERIES IN CATTLE
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Date
2019-06
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The study was carried out to evaluate the feasibility of Romifidine,
Dexmedetomidine and Xylazine sedation for Ketamine-Isoflurane general anaesthesia for
various surgeries in cattle. The study was carried out in 18 clinical cases of cattle
presented for various major surgical procedures randomly divided into three groups
consisting of six cattle in each group. The animals of Group I were administered with
Romifidine (10 µg/Kg, I/V) followed by Ketamine hydrochloride (3 mg/Kg, I/V) and
maintained with Isoflurane (1-2%). The animals of Group II were administered with
Xylazine hydrochloride (0.1 mg/Kg, I/V) followed by Ketamine hydrochloride (3 mg/Kg,
I/V) and maintained with Isoflurane (1-2%). The animals of Group III were administered
with Dexmedetomidine (2.5 µg/Kg, I/V) followed by Ketamine hydrochloride (3 mg/Kg,
I/V) and maintained with Isoflurane (1-2%). Faster induction time, early onset of
sedation, early recovery time to regain sternal position and to assume standing position
were noticed in cattle premedicated with romifidine than cattle premedicated with
Dexmedetomine and Xylazine for Ketamine-Isoflurane general anaesthesia. Romifidine
as a premedicant provided better analgesia, degree of sedation and muscle relaxation
compared to dexmedetomidine and Xylazine whereas, after induction of general
anaesthesia it was excellent in all the groups. Respiratory depression, bradycardia and
decrease in mean arterial pressure were more severe in cattle premedicated with
Romifidine and Xylazine when compared to cattle premedicated with Dexmedetomidine
for Ketamine-Isoflurane anaesthesia. Heamato-biochemical parameters fluctuated within
normal limits. Hence in present study we can conclude that, Romifidine was more
powerful sedative than Xylazine and Dexmedetomidine, during Ketamine-Isoflurane
induced general anaesthesia in cattle