Cytopathological and immunohistochemical assessment of mammary tumors in male dogs
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Date
2020
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Abstract
Three male dogs aff ected with mammary tumors brought for treatment were aged 7 to 10 years. Tumor was noted at right
caudal thoracic in one dog and left caudal thoracic region in two dogs. The mean haemato-biochemical parameters revealed
no alterations except leucocytosis associated neutrophilia and elevated blood urea nitrogen and creatinine. The serum sex
hormones estradiol and progesterone were increased, whereas, testosterone values were unaltered. Grossly, cut surface of the
tumor mass from one dog revealed greyish white, blood tinged and caulifl ower like growth. Fine needle aspiration smears
revealed neoplastic cells mixed with infl ammatory cells. Histopathologically the tumor mass revealed extensive proliferation
of dense fi brous tissue, area of chondroid diff erentiation and transformation of fi broblast into cartilage. Proliferating neoplastic
cells showed degeneration, necrosis and infi ltration of infl ammatory cells. Immunohistochemical analysis of tumor
tissues revealed triple negative phenotype for estrogen and progesterone receptors and Human Epidermal Growth Factor-2,
but positive reaction for cytokeratin. Clinico-pathological investigations and immunohistochemical features were consistent
in diagnosis of mammary tumors in male dogs.
Description
TNV_IJVP_2020_44(1)7-10
Keywords
Veterinary Science