PHARMACOKINETICS AND BIOAVAILABILITY OF TIAMULIN IN BROILER CHICKEN

Loading...
Thumbnail Image
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The present study was carried out to investigate the pharmacokinetics of tiamulin in broiler chicken following administration through oral (directly into the crop), drinking water and feed at the dose rate of 40 mg/kg body weight and also to investigate the residue status of tiamulin in edible tissues. Commercial broiler chicken were used for the study. Tiamulin was administered as mentioned above and the blood samples were collected at predetermined time intervals for separation of plasma. Concentration of tiamulin in the plasma samples was assayed using a sensitive, accurate and precise HPLC technique. The pharmacokinetic parameters were calculated using non-compartmental method. The pharmacokinetic and pharmacodynamic parameters AUC24/MIC, Cmax/MIC, T>MIC were integrated to optimize tiamulin dosage in broiler chicken. The comparison of plasma concentration and pharmacokinetic parameters between three routes showed no significant difference. The concentration of tiamulin in lung was found to be above reported MIC (0.03μg/ml) up to 1 day in ‘in-feed’ and and up to 3 days in ‘in-water’ group.Relative bioavailability of tiamulin in ‘in-water’ group is 165% and in ‘in-feed’ group is 134%. Residue study in edible tissues showed that the tissue concentration was less than the stated Maximum Residue Limits (MRL) on day 3 after last dosing of tiamulin at 40 mg/kg b.wt (for 3 days in drinking water and feed). Based on the results of the study, it is concluded that administration of tiamulin through drinking water and feed at the dose rate of 40mg/kg b.wt is found to be suitable therapeutically in broiler chicken which can be recommended for treatment of chronic respiratory disease and other susceptible infections.
Description
TNV_TH_MVM 16052_2018
Keywords
Veterinary Science
Citation