Assessment of Humoral Immune Response in Rabbits Fed with Cassia Occidentalis
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Date
2013-10
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Abstract
Cassia occidentalis was tested for its
humoral immuno modulatory effects by
comparing it with a proprietary
immunostimulant, levamisole HCL using
dexamethasone induced immuno suppression
model in rabbits. Thirty six male Newzealand
White rabbits were divided into six groups (I,
II, III, IV, V, and VI) of six animals in each.
Group I was the untreated control.
Group II was dexamethasone sodium
(Immunosuppressive) treated. Group III was
Levamisole Hcl (Immuno stimulant) treated.
Group IV was Cassia occidentalis treated.
Group V was levamisole and dexamethasone
treated and Group VI was dexamethasone and
Cassia occidentalis treated group. Levamisole
Hcl was given at 2.5 mg/kg subcutaneously
thrice a week, dexamethasone sodium was
given at the rate of 2mg/kg intra muscularly
for seven days and Cassia occidentalis was
given @ 1000 mg/kg orally for 10 days.
To assess the humoral immune
response, estimations of antibody titre, total
immunoglobulin concentration and
haematology were carried out. Cassia
occidentalis, Dexamethasone + Cassia
occidentalis and control groups showed no
significant differences in the estimation of
antibody titre where as dexamethasone group
showed significant decrease in the titre as
compared to other groups tested. There were
no significant changes noticed between Cassia
occidentalis, dexamethasone, dexamethasone
+ Cassia occidentalis groups in total
immunoglobulin concentration. The values of
haematology among groups tested were
insignificant. The estimation of antibody titre
in the study suggests that the methanolic
extract of Cassia occidentalis has the potential
in reversing the dexamethasone induced
immunosuppression in rabbits.
Description
TNV_SIJVS_2013_1(2)1-5
Keywords
Veterinary Science