Evan’s Syndrome – A cross sectional study of positive cases detected by flowcytometry
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Date
2020-02
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Abstract
Evan’s syndrome is an autoimmune disorder in which the immune system produces antibodies against
self RBCs or platelets. Affected dogs exhibit haemolytic anaemia and / or thrombocytopenia. Early detection
of this condition and differentiation from parasitic-induced anaemia is critical for better prognosis following
treatment. Flow cytometry was applied for diagnosis of immune mediated haemolytic anaemia (IMHA) or
immune-mediated thrombocytopaenia (IMTP) of both (Evans syndrome) based on the mean fluorescent
ntensity (MFI) analysis in 243 dogs brought to MVC Clinics between April 2018 to July 2019. Of this,
176 (72%) positive cases for either IMTP and/or IMHA were diagnosed. Among the positive cases Evan’s
syndrome was observed in 153 cases (87%), IMTP alone in 14 cases (8%) and IMHA alone in 9 cases (5%).
Evan’s syndrome was more predominant in Labrador (43%) followed by Non Descript breeds (10%), Spitz
(9%), German Shepherd (7%), Golden Retriever (5%), Cross breed (5%), Beagle (5%), etc. On both RBCs
(83%) and Platelets (84.7%) a combination of IgG and IgM antibodies were more prevalent. There was no
correlation between the surface immunoglobulin isotypes of IgG or IgM with reduction in haemoglobin,
packed cell volume, RBC, WBC and platelet counts. No correlation was also seen between the MFI and
clinical severity of the anaemic disease.
Description
TNV_20thMVC_PP_Feb-2020_PA31
Keywords
Veterinary Science