GENETIC POLYMORPHISM OF BMP2 (EXON2) GENE IN MECHERI SHEEP
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Date
2019
Authors
Journal Title
Journal ISSN
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Publisher
Indian Society for Sheep and Goat Production and Utilization
Abstract
Bone morphogenetic protein (BMP) genes are
members of the transforming growth factor beta
(TGF- ) super-family, which ! are multifunctional
cytokines with a two-fold function and expressed in a
variety of cells. BMPs were originally identified on the
basis of their ability to produce ectopic bone formation
when implanted within soft tissue in vivo. They also
play roles in embryonic development, homeostasis,
repairing of various t issues pat terning, cel l
differentiation and apoptosis (Supakorn, 2009). These
genes are located on the X chromosome in sheep
(Ghoreishi et al., 2011). The BMP2 gene is associated
with osteoporosis, promotes osteoblast differentiation
and bone formation and repair of bone defects in
mammals (Yue et al., 2005; Choi et al., 2006;
Schrauwen et al . , 2008) . In recent years,
polymorphism of BMP2 gene and its association with
growth traits in livestock and poultry has been reported
(Fang et al., 2010; Li et al., 2012). Realising the
importance of sheep in Indian economy, particularly in
rural economy, the present study with the objective of
determining the polymorphism of BMP2 genes was
undertaken in Mecheri sheep.
Description
TNV_IJSR_2019_25(2)234-235
Keywords
Veterinary Science