Hepatoprotective Effect of Aqueous Extract of Gyrocarpus asiaticus on Paracetamol Induced Hepatotoxicity in Zebra Fish
Loading...
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Excellent Publishers
Abstract
Paracetamol induced hepatotoxicity is a common model for accessing the hepatoprotective
nature of new molecules. This study was conducted to evaluate the potential of aqueous
extract of Gyrocarpus asiaticus on paracetamol induced hepatotoxicity in zebra fish. Fish
were challenged with 20mM concentration of paracetamol followed by treatment with
aqueous extract of Gyrocarpus asiaticus. Serum was evaluated for alanine transferase
(ALT) concentration and liver samples were collected for histopathological analysis.
Result of this study showed that, there was marked elevation of ALT in induced group and
compare to paracetamol induced toxicity group, Gyrocarpus asiaticus treated group has
got marked reduction in ALT which also confirmed through histopathological analysis,
where the treatment group showed normal morphological features. Hence further study can
be done to elucidate the mechanism of action of Gyrocarpus asiaticus through molecular
level to have a confirmation of hepatoprotective nature of this plant.
Description
TNV_IJCMAS_2019_8(4)2260-2265
Keywords
Veterinary Science