Comparative immunoprophylactic efficacy of Haemonchus contortus recombinant enolase (rHcENO) and Con A purified native glycoproteins in sheep
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Date
2015
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Abstract
Haemonchus contortus is the most economically important blood feeding nematode parasite of sheep and
goats all over the world. Enolase in helminth parasites is a multi-functional enzyme which involves in
glycolysis and host tissue invasion. In this study, the recombinant H. contortus enolase (rHcENO) was evaluated
for its immunoprophylactic efficacy in sheep along with Con A purified native glycoproteins in a
vaccine challenge trial. Group I and Group II experimental sheep were immunized thrice with rHcENO
and Con A purified native glycoproteins along with Montanide ISA 61 VG adjuvant. The animals were
challenged with 5000 L3 stage active H. contortus larvae after 21 days of third immunization. A significant
increase in the IgG titre was observed in rHcENO and Con A purified native glycoproteins immunized
animals as compared to the control animals. Immunoprotective efficacy of Con A purified native glycoproteins
was comparatively higher than rHcENO antigen.
Description
TNV_EP_154_2015_98
Keywords
Veterinary Science, Veterinary Parasitology