STUDIES ON POSITIVE PRESSURE VENTILATION DURING ANAESTHESIA IN DOGS
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Date
2017-08-27
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CSKHPKV, Palampur
Abstract
The study was undertaken to clinically standardize the positive pressure ventilation with anaesthesia in clinical settings. The study was designed as prospective clinical trials carried out on 20 client owned dogs divided into two groups which were designated as group ATRA (Atracurium) and group VECU (Vecuronium) with 10 dogs in each group. A total of 7 ophthalmic and 3 orthopedic procedures were performed under IPPV in ATRA group and 6 ophthalmic and 4 orthopedic procedures in VECU group. Animals of both ATRA and VECU groups received Inj. Butorphanol @0.2 mg/kg b.wt. I/M followed 30 minutes later with Inj. Atropine sulphate @0.04 mg/kg b.wt. S/C. Ten minutes later, premedication with Inj. Diazepam @0.5 mg/kg b.wt. I/V followed by Inj. Propofol "till effect" I/V for induction of surgical anaesthesia. Following induction, the animal was maintained on Isoflurane. After stabilizing the animals on isoflurane for five minutes, the muscle relaxation was induced using Inj. Atracurium @0.5 mg/kg b.wt. I/V in ATRA group and Inj. Vecuronium @0.1 mg/kg b.wt. I/V in VECU group and the animals were shifted to the volume controlled IPPV mode of the ventilator with the settings as respiration rate at 15 breaths per minute, tidal volume at 10 ml/kg b.wt. and inspiratory to expiratory ratio of 1:2. The eye ball deviated to ventromedial position after the induction with diazepam and propofol but resumed the central position within 30 seconds of atracurium and vecuronium administration, thus proving highly beneficial for the globe and corneal interventions. The muscle relaxation facilitated easy manipulations in the orthopedic procedures. The atracurium provided muscle relaxation for 40.1 ± 4.71 minutes and vecuronium provided muscle relaxation for 37.7 ± 1.01 minutes. The IPPV with NMBA had isoflurane sparing effect. Both the combinations with Atracurium and Vecuronium along with IPPV minimally altered the physiological parameters without any clinical consequences, thus can be considered complication free anaesthesia for procedures necessitating muscle relaxations.
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