A clinical study on efficacy of natural and synthetic suture materials vis-a-vis antiadhesion measures in bovine caesarean section

Loading...
Thumbnail Image
Date
2007
Journal Title
Journal ISSN
Volume Title
Publisher
Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana
Abstract
The present study was undertaken to assess a) comparative efficacy of chromic catgut (CC)/polyglycolic acid (PGA) suture materials on survival rate and subsequent fertility in caesarean operated bovines, b) clinical efficacy of sodium carboxy methyl cellulose (SCMC) in preventing uterine adhesions following caesarean, c) degree of uterine adhesion formation following above interventions with the help of histopathology and by moniton'9biochemical profile of plasma and peritoneal fluid and d) to study prevalence of microflora in uterine fluid before and after caesarean. A total of 41 animals were used in the present study, and on the basis of type of material used for suturing uterine incision, either with or without intra-peritoneal SCMC infusion during caesarean, these were divided into 4 groups (PGA+SCMC-gp IA, n=12; PGA-gp IB, n=10; CC+SCMC-gp IIA, n=10 and CC-gp IIB, n=9). Again, on the basis of duration of dystocia 3 groups were formed (<12 hr­gp A, n=11; 12-36 hr-gp B, n=12 and >36 hr-gp C, n=18). Pre-caesarean blood histamine, plasma fibrinogen, blood urea nitrogen, plasma creatinine, peritoneal fluid fibrinogen and total proteins, peritoneal and uterine fluid neutrophil concentrations in gps IA and IIA decreased significantly (P<0.10-0.05) during post-caesarean period. However, concentrations of these parameters in gp IIB, increased invariably during post-caesarean period and were also higher in delayed cases of dystocia compared to fresh cases. Pre-caesarean concentrations of total plasma proteins, peritoneal and uterine fluid lymphocytes in gps IA and MA, increased while in gp MB, their concentrations decreased significantly (P<0.10-0.05) during post-caesarean period. Duration of dystocia also had adverse effect on the concentrations of all these parameters. No variation was observed between pre and post-caesarean concentrations of serum ceruloplasmin and plasma creatine kinase in various groups. However, in gp IIB, the pre-caesarean serum ceruloplasmin concentration increased significantly (P<0.05) on days 2 and 3 post-caesarean. Serum ceruloplasmin and plasma creatine kinase concentrations also increased significantly (P<0.05) with increase in duration of dystocia. Uterine histopathology in all dystocia affected animals revealed mild to severe epithelial/ subepithelial, muscular and endometrial glandular damage, whereas, superficial inflammatory changes varied from acute to chronic. When PGA was used with SCMC, severity of epithelial and muscular damage decreased on day 6 post-caesarean. The severity of uterine tissue damage increased with increase in duration of dystocia. The most prevalent bacterium isolated in uterine fluid at the time of caesarean was E. coli. However, Arcanobacter pyogenes was the predominant bacterium at days 30-40 post-caesarean. Maximum survival rate (75%) was observed in animals where PGA and SCMC was used. In fresh cases of dystocia survival rate (72.7%) was significantly (P<0.05) higher than in delayed cases (33.3%). Severity of uterine adhesions was less in animals where PGA and SCMC was used. Retrospective analysis of caesareans conducted at field level revealed a survival rate of 65.6 per cent.
Description
Keywords
Citation
Collections