Effect of dobutamine and epinephrine for maintenance of cardiovascular parameters in bovine subjected to general anaesthesia
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Date
2014
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Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana
Abstract
The present study was conducted in 50 clinical cases of bovine presented for repair of diaphragmatic hernia. All animals were female, 48 buffaloes and 2 cattle. The induction of general anaesthesia was done using a combination of butorphanol @ 0.05mg/kg IV and midazolam @ 0.2mg/kg IV followed by ketamine @ 5mg/kg IV. Anaesthesia was maintained with isoflurane in combination with oxygen. Animals were categorised in groups I, II, and III on the basis of maintenance of various cardiovascular parameters. Animals where cardiovascular parameters were maintained above critical range were categorised into group I. Adminstration of epinephrine (group II) and Dobutamine (group III) was practiced in animals where arterial blood preesure were below the critical range. Hypernatremia, hypokalemia and hyperchloremia were the major electrolyte alterations. Decrease of pHa, pO2 and increase of pCO2 were the major acid base changes in all groups. Positive pressure ventilation was useful for maintaining pH, pO2, and pCO2. Pulse rate was within the normal range. Venous pressure values showed significant elevation. Significant decrease in SBP, DBP and MAP was observed in all the animals of groups II and III. Administration of epinephrine and dobutamine was effective in maintenance of blood pressure and pulse rate above the critical range. Respiratory rate showed no significant alteration. Decrease in rectal temperature was observed throughout the post anaesthetic period. Decline in oxygen level from base value was observed after taking animals to dorsal position. Haemoglobin and PCV values fluctuated below the base values throughout the observation period. No difference in the values of BUN was seen. Base values of creatinine were markedly higher in groups II and III than the normal values. Haemodynamic alterations were more prominent in animals with severely altered creatinine levels. Anaesthetic combination and ionotropic drugs did not produce any untoward effect of renal and hepatic functions