EVALUATION OF TOXICITY MANIFESTATIONS ON VITAL ORGANS FOLLOWING REPEATED EXPOSURE OF INDOXACARB ALONE AND IN COMBINATION WITH CADMIUM
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Date
2017
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Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu
Abstract
This investigation was undertaken to evaluate the hepatic and renal oxidative damage due to sub-acute exposure of indoxacarb alone and the effect of cadmium in modulating indoxacarb induced damage in Wistar rats. 36 male Wistar rats weighing 150-180g were randomly divided into six groups with six rats in each. Group I served as control and group II (indoxacarb @173mg/kg b.wt.), III (indoxacarb @346mg/kg), IV (cadmium @ 100ppm), V (indoxacarb @ 173mg/kg plus cadmium @ 100ppm) and VI (indoxacarb @ 346mg/kg plus cadmium @100ppm) served as respective toxicant exposed groups during this 28 days study. Indoxacarb administered @ 173mg/kg daily for 28 days reduced protein level but elevated biochemical indices like phosphatases (ACP & ALP), aminotransferases (AST & ALT) in plasma. At 346mg/kg dose it enhanced plasma aminotransferases and ALP. Indoxacarb in both selected doses was capable of inducing peroxidation of RBC with decline in its glutathione levels. Decrease in the activities of other oxidative stress enzymatic components like SOD, GPx, was observed at higher dose of indoxacarb. These oxidative changes got more pronounced in blood, when coexposed with cadmium. The results revealed that indoxacarb is capable of producing hepatotoxicity, which is evidenced by alteration in its oxidative stress parameters. Such changes were more pronounced when rats were co-exposed to cadmium and indoxacarb. Blood biomarkers of renal function viz BUN & creatinine was also altered with indoxacarb and cadmium individually, but such alterations were more prominent in the groups coexposed to indoxacarb and cadmium. Enzymatic antioxidant parameters and lipid peroxidation in renal tissues were altered in indoxacarb alone and in combination with cadmium indicating oxidative damage to renal tissues. It can be concluded from the study that cadmium has a potentiating effect on the toxicity of indoxacarb in rats. This study will help in determining the suitability of indoxacarb in cadmium endemic areas.
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