STUDIES ON THE PHARMACOKINETICS AND BIOTRANSFORMATION OF FENBENDAZOLE AND TRICLABENDAZOLE IN CALVES
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Date
1994
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AAU, Anand
Abstract
In the present study, detailed pharmacokinetics and biotransformation of FBZ were investigated in healthy buffalo calves and those fed different diets or subclinically infected with nematode parasites. The detailed pharmacokinetics and biotransformation studies of the drugs were carried out in buffalo calves and cow calves after administration of TCBZ and in buffalo calves following co-administration of FBZ with TCBZ. In addition, the influence of diet on the pharmacokinetic behaviour of TCBZ metabolites was investigated in cow calves. Following FBZ administration or ingestion, FBZ, OFZ and FBZSO2 were detected in plasma of buffalo calves. After intraruminal administration of FBZ (7.5 mg.kg-1), the pharmacokinetics of FBZ and its metabolites were best described by a one-compartment open model in subclinically infected and healthy buffalo calves fed different diets.
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VETERINARY PHARMACOLOGY, A STUDY