Ameliorating potential of extracts of eucalyptus and clove against toxicity induced by sub-acute exposure of thiacloprid in rats
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Date
2017
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Rajasthan University of Veterinary and Animal Sciences, Bikaner
Abstract
The present study was carried out to evaluate ameliorating potential of extracts of Eucalyptus, Clove and it’s combination (1:1) against toxicity induced by sub-acute exposure of thiacloprid in rats. The main clinical signs observed was piloerection, decreased motility and reactivity, poor reflexes, spastic gait, spasmodic state, convulsions, tremor, tachypnea, dyspnea, labored breathing, diarrhoea, narrowed palpebral fissure, closed eyelids and red incrusted snout sub-acute intoxication induced decrease body weight ,absolute organ weight and relative organ weight of liver, kidney, spleen respectively which were significantly restored by eucalyptus and clove extract. Moreover there was significant decrease in TEC, Hb, PCV, MCH, DLC (neutrophil, lymphocyte) values while TLC increased in thiacloprid treated rats. On the other hand eucalyptus, clove and their combination increase these haematological values except TLC. There was a significant increase in serum biochemical parameter related to hepatic and renal injury like ALT,AST,LDH and creatinine which were restored by eucalyptus, clove and their combination (1:1). Thiacloprid treatment resulted in oxidative stress by increased LPO, and decreased GSH, SOD, Catalase levels as compared to control animals which was normalized by Eucalyptus, Clove, combination of eucalyptus and clove co-treatment with thiacloprid partially. Histopathological findings revealed that thiacloprid produced a mild to moderate degenerative changes in liver, kidney, brain and spleen which were minimized by Eucalyptus, clove and combination of eucalyptus and clove co-treated with thiacloprid respectively. In general, it was conducted that eucalyptus and clove are able to protect against thiacloprid induced toxicity.
Keywords- Eucalyptus, clove, thiacloprid , sub-acute toxicity.
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