Assessment of the Immune Status in “Withaferin A” Treated Rats in Experimental Mammary Carcinogenesis by Flow Cytometry
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Date
2018-01
Journal Title
Journal ISSN
Volume Title
Publisher
TANUVAS
Abstract
The present study was carried out to evaluate
the immunomodulatory effect of Withaferin A
in DMBA (7,12-dimethylbenz[a]anthracene)
induced mammary carcinogenesis in rats.
Twenty four female Sprague-Dawley (SD) rats
were equally distributed to control, DMBA,
DMBA+Tamoxifen (Standard drug) and
DMBA+Withaferin A groups. Peripheral blood
was collected at the 120th day from the initial
dose of DMBA and CD3, total T lymphocytes
were determined by using ow cytometry. There
was signi cant (P<0.05) increase in the total T
lymphocytes (CD3) in the DMBA+Withaferin A
group from DMBA+Tamoxifen group indicating
immunostimulatory effect of Withaferin A.
Description
TNV_IVJ_Jan2018_V95_I01_33-35
Keywords
Veterinary Science