Synthesis of halogenated chalcones and their antifungal evaluation
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Date
2017
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Punjab Agricultural University, Ludhiana
Abstract
Chalcone is a generic term used to describe compounds with the 1,3-diphenylprop-2-en-1-one
framework. On synthetic ground, chalcones are synthesized by Claisen-Schmidt condensation
reaction which involved the base mediated reaction of andifferent aldehydeswith different
ketone in presence of strong bases like sodium hydroxide and potassium hydroxide. In the
present study, series of novel halogenated chalcones (1-14) were synthesized through ClaisenSchmidt
condensation reaction between different halogenated aldehydes and α, β-unsaturated
halogenated ketonesunder basic conditions. The synthesized compounds were formulated as
nano aqua emulsions using oleic acid as oil phase with Tween 20 as surfactant,under
ultrasonic irradiation. Antifungal activity of prepared chalcone nanoemulsions was tested
against various phytopathogenic fungi viz. Pyriculriagrisea, Dreschslera oryzae,
Colletotrichum falcatum and Ustilago hordei. The results indicated that the various
synthesized halogenated chalcones showed mild activity against various fungi.
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