Allogenic Adipose Derived Stem Cells with Chondrogenic Bioactive Factors for Articular Cartilage Regeneration in Canine Osteoarthritis
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Date
2014
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Publisher
TANUVAS, Chennai
Abstract
The current study was performed to evaluate the efficacy of intra-articular
engraftment of canine adipose-derived mesenchymal stem cells (cADMSCs) with and
without chondrogenic bioactive factors namely, ascorbic acid and dexamethasone
mixture (ADM) on regeneration of articular cartilage in osteoarthritis (OA) of hip and
stifle joints in dogs. Eighteen (N=18) joints satisfying the prescribed inclusion and
exclusion criteria were included in the study. The selected cases were divided into three
treatment groups of 6 joints (n=6) per group. ADM and cADMSCs of allogenic origin
derived from omental fat were engrafted intra-articularly into the osteoarthritic hip and
stifle joint by performing ultrasound guided intra-articular injection after undertaking
strict aseptic precautions. The incidence of OA of the hip and stifle joint were studied
among different breeds, joint affected and sex across various age groups, weight and
nutritional status adopted. The efficacy of regeneration of articular cartilage was
assessed using owner’s score, Olby score, lameness score, clinical examination, synovial
fluid analysis, radiographic and ultrasonographic evaluation.
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Keywords
Veterinary Science, Veterinary Surgery and Radiology