BIOPROSPECTING OF ANTICANCER POTENTIAL OF SOME MEDICINAL PLANTS
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Date
2015
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Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu
Abstract
Present study was undertaken with the objective to explore the anticancer potential of Alstonia scholaris, Nerium oleander. Cannabis sativa and Brassica leracea. All the extracts and their fractions of plants under study were evaluated for their in vitro and in vivo anticancer potential, DNA ladder assay, AMES assay and in vitro antioxidant potential i.e. total antioxidant capacity (TAC), free radical scavenging activity-DPPH assay (FRSA) and reducing power (RP). Additional phytochemical (viz. total phenolic, falvonoid, tannin and non tannin content), proximate principal, fiber fraction and mineral analysis was also done. Only NODC, CSMC and ASDH were found to be the active fractions with in vitro anticancer activity. All the active fractions produce in vitro anti cancer activity by apoptosis, had shown moderate in vivo anti cancer activity against Eharlic tumor (solid) and were found non mutagenic by AMES assay. Both the extract of all the plants had a good quantity of IPC, TFC, TTC and NTC as a result the active fraction of these plants had shown promising TAC, FRSA and RP. All the plants under study had high contents of proximate principles, fiber fractions and minerals as well. The conclusion of work is that all the plants under study need to be studied against a panel of more number of cancer cell lines and murine cancer models before going for anticancer drug discovery from the plants.
Keywords: Anitcancer, Phytochemical, AMES assay, DNA fragmentation, In vitro antioxidant Alstonia scholaris, Nerium oleander, Cannabis sativa and Brassica oleracea.
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No. of references 183