PATHOMORPHOLOGY OF UTERINE NEOPLASIA IN INFERTILE CROSSBRED COWS
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Date
2013-03
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SRI VENKATESWARA VETERINARY UNIVERSITY , TIRUPATI – 517502. (A.P.) INDIA
Abstract
ABSTRACT :
The objective of the present study was to ascertain the prevalence and cytological, histopathological description of uterine neoplasia in infertile crossbred cows. To fulfill the objective, cytopathology, histopathology and AgNOR were taken up. In the present study clinical and gross observations in slaughter house crossbred genitalia were uterine wall thickening (61.53%), purulent discharge (21.15%), slimy discharge (9.61%), whitish foci over endometrium (21.15%), endometrial congestion (11.53%), petechiae over caruncles (7.69%) and atrophied caruncles (flattened endometrium) (5.76%). Furthermore clinical observations in infertile crossbred cows noticed were thickened uterus (73.68%), extended estrus duration (68.42%), irregular estrus cycle (78.94%), and copious discharge (52.63%). Cytological studies revealed abnormal cellular pattern suspicious of neoplasia in 82.69% in slaughter house genitalia and 42.10% in infertile crossbred cows. Whereas, 17.30% slaughter house genitalia and 57.89% infertile crossbred cows presented normal epithelial cellular pattern. Based on histopathological studies 73.07% neoplasia and 21.15% dysplasia in slaughter house genitalia, whereas 31.57% neoplasia and 5.26% eosinophilia in infertile crossbred cows. However chronic endometritis was found in 5.76 and 5.26% in slaughter house genitalia and infertile crossbred cows, respectively. The neoplasms recorded in slaughter house crossbred genitalia were adenocarcinoma (65.78%), followed by lymphosarcoma (7.90%), haemangiosarcoma and haemangiosarcoma with adenocarcinoma both accounted to 5.26% each. In adenocarcinoma, histiocytic adenocarcinoma, scirrhous adenocarcinoma, clear cell adenocarcinoma, and papillary adenocarcinoma were accounted to 20 (5), 12 (3), 12 (3) and 4% (1), respectively. Other neoplasms reported were histiocytoma, fibrosarcoma, leiomyosarcoma, myxosarcoma, leiomyosarcoma with haemangiopericytoma, leiomyosarcoma with adenocarcinoma and lymphosarcoma with adenocarcinoma each accounted to 2.63%. Whereas in infertile crossbred cows the highest prevalence of the neoplasm in uterus was adenocarcinoma, haemangiosarcoma accounted to 50% each. In adenocarcinoma, clear cell adenocarcinoma accounted to 33.33%. The mean AgNOR count varied from 5.2 to 8.7 with a mean of 6.45 ± 0.06 per cell in neoplasia. Whereas for dysplasia and chronic endometritis AgNOR count varied from 4.0 to 4.3 and 3.1 to 3.2 with a mean of 4.17 ± 0.09 and 3.16 ± 0.10 per cell, respectively. The AgNOR counts significantly differed between groups (P ≤ 0.05). Finally it was concluded that uterine neoplasia could be one of the contributing factors to infertility and special focus may be given to cytopathology so as to initially screen the chronic infertile cows for neoplasia.
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