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Kerala Agricultural University, Thrissur
The history of agricultural education in Kerala can be traced back to the year 1896 when a scheme was evolved in the erstwhile Travancore State to train a few young men in scientific agriculture at the Demonstration Farm, Karamana, Thiruvananthapuram, presently, the Cropping Systems Research Centre under Kerala Agricultural University. Agriculture was introduced as an optional subject in the middle school classes in the State in 1922 when an Agricultural Middle School was started at Aluva, Ernakulam District. The popularity and usefulness of this school led to the starting of similar institutions at Kottarakkara and Konni in 1928 and 1931 respectively.
Agriculture was later introduced as an optional subject for Intermediate Course in 1953. In 1955, the erstwhile Government of Travancore-Cochin started the Agricultural College and Research Institute at Vellayani, Thiruvananthapuram and the College of Veterinary and Animal Sciences at Mannuthy, Thrissur for imparting higher education in agricultural and veterinary sciences, respectively. These institutions were brought under the direct administrative control of the Department of Agriculture and the Department of Animal Husbandry, respectively. With the formation of Kerala State in 1956, these two colleges were affiliated to the University of Kerala. The post-graduate programmes leading to M.Sc. (Ag), M.V.Sc. and Ph.D. degrees were started in 1961, 1962 and 1965 respectively.
On the recommendation of the Second National Education Commission (1964-66) headed by Dr. D.S. Kothari, the then Chairman of the University Grants Commission, one Agricultural University in each State was established. The State Agricultural Universities (SAUs) were established in India as an integral part of the National Agricultural Research System to give the much needed impetus to Agriculture Education and Research in the Country. As a result the Kerala Agricultural University (KAU) was established on 24th February 1971 by virtue of the Act 33 of 1971 and started functioning on 1st February 1972. The Kerala Agricultural University is the 15th in the series of the SAUs.
In accordance with the provisions of KAU Act of 1971, the Agricultural College and Research Institute at Vellayani, and the College of Veterinary and Animal Sciences, Mannuthy, were brought under the Kerala Agricultural University. In addition, twenty one agricultural and animal husbandry research stations were also transferred to the KAU for taking up research and extension programmes on various crops, animals, birds, etc.
During 2011, Kerala Agricultural University was trifurcated into Kerala Veterinary and Animal Sciences University (KVASU), Kerala University of Fisheries and Ocean Studies (KUFOS) and Kerala Agricultural University (KAU).
Now the University has seven colleges (four Agriculture, one Agricultural Engineering, one Forestry, one Co-operation Banking & Management), six RARSs, seven KVKs, 15 Research Stations and 16 Research and Extension Units under the faculties of Agriculture, Agricultural Engineering and Forestry. In addition, one Academy on Climate Change Adaptation and one Institute of Agricultural Technology offering M.Sc. (Integrated) Climate Change Adaptation and Diploma in Agricultural Sciences respectively are also functioning in Kerala Agricultural University.
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ThesisItem Open Access Effect of planting date, weight of rhizome and spacing on the growth, yield and quality constituents on turmeric (Curcuma longa L)(Department of Horticulture (Plantation Crops & Spices), College of Horticulture, Vellanikkara, 1983) Chatterjee, R K; KAU; Mohanakumaran, NThesisItem Open Access Genetic variability, path analysis and stability parameters in sesame(Department of Plant Breeding, College of Agriculture, Vellayani, 1985) Sverup, John; KAU; Gopinathan Nair, VBiometric analysis in a varietal collection of sesame was undertaken to study the genetic variability, correlations, path analysis and stability parameters. One hundred sesame types were evaluated in replicated trials at Vellayani in uplands during rabi and at Kayamkulam in rice fallows during summer. Genetic variability and correlations were estimated and path analysis worked out independently as both the locations. Location trials for estimating stability parameters were conducted at three places viz. in uplands during rabi at Pattambi and Vellayani and in rice fallows during summer at Kayamkulam. Large values for genotypic coefficients of variation were obtained for characters such as number of capsules on branches, number of capsules perplant, number of capsules on main stem and number of branches during rabi as well as summer. The lowest genotypic coefficient of variation was obtained for number of days to maturity during both rabi and summer. High values of heritability were recorded by seed protein content , seed oil content, height upto first capsule and weight of 1000 seeds under both conditions.ThesisItem Open Access Cytogenetic studies on intervarietal hybrids of sesamum (Sesamum indicum L.)(Department of Agricultural Botany, College of Agriculture Vellayani, Trivandrum., 1984) Chandramony, D; KAU; Krishnan Nair, NThesisItem Open Access Effect of NPK on seed progeny and air layers in cashew ( Anacardium occidentale L. )(Department of agronomy, College of Agriculture Vellayani , Trivandrum, 1985) Harishu Kumar, P; KAU; Sreedharan, CAn experiment was conducted to assess the "Ef f e c t of NPK fertilisers on seed orogeny and air layers in cashew at Cashew Seed Farm, Shanmtigodu under Central Plantation Crops Research Institute , Regional Station, f i t c a l 574 24 3, during 1982-84. fhe treatments consisted of test ing three le v e ls each of d,? and K on seed . rogen/ i.,d ai r layers Ln cashcv/. r ’ne study revc ile 1 t h . t d i f f e r en t grov.'th oar meter 7 i. e . , he L'jl'it, can>py rolLus, surf ice area, le a f area n ; : ; v/erc influenced by increasing le v e ls of I:PR. f ■ r t i I i. s e r s . [' r/ ii chlorophyl l , to I; il v.ug ir , le.it v; .ter f-,■ n* , in-: sp e c i f ic le if w ight v;ere influenced by » b ,n v/11 i I e n i t rci' p n 11 one i n c i i iset i , , ., ii c * * . I', i r 1 y i'ii s r: u I: i- c ’ i I i r r - • * * in f l o w e r i n g , numbt l r, f ft mi. t e, _ .m ,lg ,■ I ; -I -,l puilr-h t'< t-i.l il 'hoots WC IX ; i ? V i . r ‘ I i I -■ 1 nr r r 1.0,1 b y f.f r » i I i d L >n . t’rmt j;un ii r‘ rc rn> r ri o nl; inrl acc' u b i ^ ici-1 c o n t e n t , ] Lc if ion . /c r | , 7 0 1 1 0 ' J W l ! " l p l Mut v Jupic an 1 IglTt wctr drrrc ir.ecl due to d M M, ion w,lH. V ipol ic .Llon ( ivour* rl nut md P i p d i ' - 1 , 4-r d W- i n ( k c - T l u 1 n - Leaf N v;as increased by NPIC. Lear ? was increased by p and K appl icat ion v/hile i t was reduced by N appl icat ion. Leaf K was reduced by H appl icat ion while i t was increased by ? and K appl icat ion. N appl ication resul ted in an Increase in le a f C i, where as P and K reduced i t . M and K reduced le a f Mg while P had no e f f e c t . M increased lui f Zn while P reduced the same. K had no e f f e c t . Cr i t ical levels in Ic if for M and ? are f ixed at 2.09% and 0.14% respectively. hoot CSC was increased by UP.' f e r t i 1 is ition . .1 application reduc’d organic carbon and P ‘./hale- i t i.nere -Scd ^>oil M, h and oH. P appl ication increased o i l d, K and pH. ‘V. ipol icat ion incr*. ia«_ , roi l H, h and oH wher>- as i c r c r\ v c c r: o i l P • rj ind P f spons r, r*. curvul in«. ar while not as i u ■ esnonrs v m Jincir. rhc od.imuni of U and P r , pc-j/trr ,./y ai re no-. c t ivt 1 y . M ixvv.um income W L. 1. ' - * * r t ' l i - r r l In lie 1 IV- r r . rThesisItem Open Access Influence of applied nutrients and stage of harvest on the yield and physicochemical properties of essential oil of palmarosa (Cymbopogon martini Stapf var. motia)(Department of Soil Science and Agricultural Chemistry , College of Agriculture, Vellayani, Trivandrum, 1985) Chinnamma, N P; KAU; Aiyer, R SPalmarosa, an essential oil crop introduced in Kerala, from Maharashtra, nearly two decades ago, is spreading steadily la the pialas and midland regions of North Kerala. Several agro-techniques have yet to he standardised for the commercial cultivation of this crop in the State. The present studies were undertaken at the Aromatic pnfl Medicinal Plante Research Station, Odakkaly during 1980-'8 4 to obtain information on the nutrition of palmarosa, optimum harvest intervals to ensure maximum herbage and oil yields and the factors influencing the quality of oil. The treatments in the major field experiment (1980-'82) consisted of three levels of N, and KgO, each at 25, 50 And 75 kg/ha along with six intervals of harvest at 40, 45, 50, 55, 60 and 65 days. The total number of treatment combinations wore 162 in a 3^ x 6 confounded asymmetrical factorial design. Tho main experiment was continued for another two yoaro limiting tho observations, to the yield of herbage and oil. This was then followed by an observation trial with intervals of harvest longer than tho maximum of 65 doye tried in the main experiment. In the main experiment the herbage yield vns significantly increased by application of P2°5 ^2°* Nitrogen did not have any eignifioant offeot on herbage yield poaeibly due to tha medium level etatua of soil N in the ABSTRACT ^erimental plots. The oil yield was Bignifioantly enhanced by P205 application at 50 kg/ha. Different levels and K showed no significant influence on the yield of oil. Harvest intervals showed significant influence on herbage yield, oil yield and oil content and the maximum value was recorded by the 65 day interval. A path analysis of the herbage yield with related cnaracters has shown that the height of the plant is the most important yield attribute influencing directly the yield of herbage. Path analysis of oil yield showed that oil yield is mainly dependent upon herbage yield. The direct effects on oil yield by yield attributes are found to be in the decreasing order of number of tillers with inflorescence, height of the plants and length of inflorescenoe. Maximum indirect affect via herbage yield is expressed by the height of the plant and length of inflorescence. All these directly and indirectly contributing factors arc soon to be markedly influenced by tho applioation of phosphorus and intervals of harvoat* Herbage yield and oil yield for various harvest lntorvalo obtained In the flrot two years wore fit tod In a Cobb-Dcughlua reoponoo function and tha expooted values «leulat«d were found to be very olooe to tho actual observed values• In thethird and fourth year of the experiment, the ghest herbage and oil yields were recorded by 60 day interval followed by the interval of 65 days, A quadratic Sanction for the data pooled over for four years was fitted to see if the data show a diminishing return with an increase in harvest interval and it was found that the optimum herbage yield and oil yield were obtained when the harvest was done at 62 and 63 days interval respectively. The final observational trial also indicated that the herbage and oil yields were maximum for a harvest interval of 65 days beyond which it decreases. Increase in the levels of both N and P tended to increase the content of geraniol and to decrease the content of geranyl acetate which are the price determining quality attributes of the essential oil. But the maximum interval of harvest viz., 65 days tried in the main experiment was not sufficient for moot of the physico-chemical properties of oil ouoh os specific gravity, refractive index, geraniol content, geranyl acotato content etc. to reach the minimum limit prescribed by 131. The observational trial showed that the oil obtained at intervale of 95 days and above satisfied the 131 specification with respect to all the phyalco-ohemioal properties of the oil. However, at thle herveat Interval the yield Itself wae considerably depressed compared to the yield at 65 day Interval. Th, eoonomloe worked out for different Intervale of harveab baaed on the ourrant market prloe of the oil paeein« as above the I SI limits as fe. 240/- per kg (oil from harvest intervals at and above 95 days) and those below them at Fs.220/- per kg (oil from harvest intervals of 55, 65, 75 and 85 days) it has been found that a wider cost benefit ratio and net return per rupee investment are obtainable for harvest intervals ranging from 65 to 85 days. However, 65 day interval has the advantage of early returns from the investment. Application of 50 kg PgO^/ha in view of its significant effect on herbage yield, oil yield and oil quality increase the net profit per rupee invested for the harvest interval of 65 days. The average removal o f II, P, K, Ca and Mg from the s o i l by palmarosa per h ecta re per year lias a lso been worked o u t . The optimum f e r t i l i s e r le v e l fo r palmarosa i s 25 kg II, 50 kg P?05 and 25 kg K20 per h ectare over an a p p lic a tio n o f spent g ra ss at 5 tonnes per h ectare per y e a r . The optimum h arvest in to r v a l i s 65 days. TIiIb would give maximum horbago y io ld , o i l y io ld ond ea rly return from in v e stm e n ts.ThesisItem Open Access Studies on certain gastro-intestinal nematodes with special reference to those found in goats(Department of parasitology, College of Veterinary and Animal Sciences, Mannuthy, 1980) Sathianesan, V; KAU; Kalyanasundaram, RLife history of Triohuris globuloss has been elucidated for the fist time using kids !q as experimental animals. Both free living and parasitic stages have been described in detail with illustrations. The prepatent period of Triohuric globuloss was found to be 85-89 days. T.globulosa failed to develop in guniea pig on experimental transmission. Haematology and histopathology of trichuriacis in kids experimentally infected with T.globulosa have been studied for the first time and heavy infection with the worm was found to cause anaemia and pathology changes in cacum of the host. Prepatent period of Strongyloides napillosus in kids infected orally with 7000 larva has been determined for the first time to be 6-7 days. Neoasoais vitulorum of calves has been found to be not transferable to oat either transplacentally or orally. In gunia pigs M.Vitulorum failed to attain sexual maturity. Calves could not be infected with infected with M.vitulorum post-nataly. Oesphagostomum colubianum of goats has been found to be not transferable to calves. Prepatent period of O.colusbionum in kids infected experimentally was found to be 40 days. Comparative efficacy of 4 anthelminties viz., Oxibendazole, thiophanate, Albendazole and Parbendazole was increased by conducting treatment trials. Against monospecific infection of Trichuris globulosa in experimentally infected kids the efficacies of Oxibendazile, thiophanate, Albendazole and Parbendazole at the recommended doses of 10mg.50mg, 10mg and 30 mg/kg body weight respectively were found to be 48.6%, 41%,47.3% and 49.3% respectively. Even at double the recommended doses the anthelminations were found to be well tolerated by the kids. Oxibendazole and Albendazole at the rate of 10mg and 10mg/kg body weight respectively were found to be 100% found to be 100 % effective against colubriformise, effective against respectively were Haemonohus contortue, trichostrongylus .Thiopanate at the recommended dosage (59mg/kg body weight) was also 100% effective against all he nematodes mentioned above except Haemonous contortus against which it was only 97% effective at that dosage. Parbendazole at the recommended dosage shedule (30mg/kg body weight) was 100% effective against the nematodes with the exception of .against which only 86.6% efficacy was noticed. Against in nature nematodes in the gastro-intestinal tract Oxibendazole and Albendazole were 100% effective whereas the efficacies of P`arbendazole and thiophanate were 85% and 74% respectively at their recommended doses. In in vitro studies the anthelmintic efficacy of Oxibendasole against Haemonchus contortus was found to be superior to that of the remaining anthelminties. In ovicidal property also, Oxibendazole was better than all the others, since it was ovicidal in 6 hours after administration whereas albendazole, thiophanate and Parbendazole were ovicidal in 8 hours, 9 hour and 11 hours respectively. Albendazole was found to be superior to al the other 3 anthelmintion in their influences on the body weight gain of treated animals closely followed by Oxibendazole. Perbendazole and thiophanate were inferior to others Judging on the basis of over all efficacies Oxibendazole and Albendazole were found to be superior to thiophanate and Parbendasole. Treatment trials with Oxibendazole, Albendazole and thiophanate against gastro-intestinal nematodes of goats have not been attempted earlier than the present study.ThesisItem Open Access Postnatal development of testis and epididymis, semen characteristics and fertility of brown- swiss crossbred bulls(Department of Animal Reproduction and Gyneacology, College of Veterinary and Animal Sciences, Mannuthy, 1981) Surendran Varma Raja, C K; KAU; Ramachandran Rao, AA systematic investigation involving the use of 24 Brown Swiss crossbred bull calves and 7 adult bulls with 62.5% exotic inheritance varying in age from 0- 360 days and 22-40 months respectively, resred and maintained at Indo-Swiss Project, Mattupatty, Kerala, was carried out in order to (a) trace the postnatal growth and development of the testis and epididymis and (b) assess the semen characteristics such as volume, initial motility, sperm concentration, live sperm count and incidence of abnormal sperms; As a corrolary to and as an integral part of this comprehensive study, 6679 semen collection particulars from the records maintained at the Indo-Swiss Project, Mattupatty and 7586 insemination data at the Crossbreeding Research Centre, Muvathuphza werecritically scrutinised to deduce freezability/discard rate of the ejaculates and the fertility potenoy of the bulls, respectively. The materials used, the salient observations made and the valid inferences drawn aare given below: Twenty four pairs of testis and epididymis collected from the bull calves were processed to study the postnatal growth and development. The pattern of growth of testis and of the epididymis was found to be curvilinear. The testicularand epididymal weights were observed to be significantly (p<0.01) correlated with the age, and body weight of the animals. A highly significant (p<0.01) correlation between epididymal weight and testicular weight was also observed. The growth rate of the seminiferous tubules appeared to be of sigmoid type. Formation of lumen in the seminiferous cords was initiated at 150 days and completed, at 180 days of age. The transformation of gonocytes to spermatogonia occurred at 150 days of age. The formation of primary spermatocytes, spermatid and spermatozoa cocurred at the age of 150 days, 300 days and 300-360 days, respectively. The process of transformation of supporting cells was initiated at 120 days and completed at 180 days of age. The transformation of immature Leydig cells to mature cells was initiated at 150 days and completed, by 180 days of age. There were distinct regional differences between the caput, the corpus and the cauda epididymis in respect of the diameter of the tubules, height of the epithelium and the degree of transformation of Epithelial lining from simple columnar to pseudostratified type. The distal part of the ductus epididymis seemed to have attained the adult size at an earlier age than the proximal. Sperms were seen in all the three regions at about 300 days. The mean values of ejaculate volume, initial motility, sperm concentration, live sperm count, sperm head abnormalities, tail abnormalities and proximal protoplasmic droplets were found to be 2.65 ± 0.84 ml, 66.24 ± 0.87%, 1599.64 ± 55.371 milions per ml of semen, 72.55 ± 1.310%, 4.91 ± 0.439%, 0.65 ± 0.045%, 6.47 ± 0.775% and 1.20 ± 0.143%, respectively. Significant (p<0.01) variations between bulls were observed in respect of sperm head abnormalities, tail abnormalities and proximal protoplasmic droplets and between months, in respect of ejaculate volume, sperm head abnormalities, free loose head, tail abnormalities and proximal protoplasmic droplets. Seasonal variation (p<0.05), however, was evident only in the incidence of tail abnormalities. Variations due to age of bulls were found to be significant (p<0.01) in the casse of ejaculate volume, sperm concentration, free loose head, middle piece abnormalities and tail abnormalities. The freezability of sperms expressed in terms of per cent of post-thawing motility was found to be 36.86. There was no seasonal effect on the freezability of sperms. The freezability rate increased significantly (p<0.01) with advancement of age of bulls. The overall rejection rate of the ejaculates was noted to be 39.80%. Most of the rejection (71.75%) was done before freezing. The pre-freezing rejection was found to be 28.55% of the total ejaculate. The post-freezing discard to be 15.74% of the frozen samples. The rejection rates of the ejaculates differed significantly (p<0.01) between months/seasons/age of the bulls. The rate of rejection was found to decrease with advancing age. The overall fertility rate of the bulls was found to be 56.06%. There were significant (p<0.01) differences in the fertility rate between months/seasons of insemination and between age of the bulls. As between bulls also, there was a significant variation (p<0.01) in the fertility rate. The significance of the observations inferences indicated above and their relevance to the implementation of cross breeding programme in Kerala were discussed briefly.ThesisItem Open Access Studies on the common ticks affecting live-stock in Kerala(Department of parasitology, College of Veterinary and Animal Sciences, Mannuthy, 1980) Rajamohan, K; KAU; Kalyanasundaram, RAn investigation was conducted for a period of 5 years from 1974 to 1979 in to the incidence of ticks on domestic animals in Kerala, the biology of the most common species, and their susceptibility to four commonly available organo phosphorus compounds.. Nine different species of ticks belonging to 5 genera were collected from cattle, buffaloes, goats and dogs in different localities of the eleven districts of Kerala. The species of ticks identified were boophilus annulatus, rhipicephalus sanguineus, R.haemaphusaloides, R.turanicus, haemaphysalis bispinosa, H. turturis, H.spinigera, Hyalomma anatolicum and Amblyomma integrum. The commonest among them was boophilus annulatus, which was found mainly on cattle. The incidence of this tick was very high in the hilly areas and in the western ghat regions. The other common ticks found on cattle were Rhipicephalus haemaphysaloides and Haemaphysalis bispinosa. Tick infestation was found to be rare in buffaloes and goats and the common species found on them were Haemaphysalis bispinosa and B. annulatus. IN dogs the species recorded in the present study were Rhipicephalus sanguienus and R. turanicus. Variations in incidence was evidenced from the present study. The maximum incidence was found in the months of July, August, September, October and November. The life-cycle of B.annulatus was completed experimentally in a period 44 days. The maximum number of eggs produced by one tick was 1420 and minimum 680. The incubation period was dependent on the room temperature and variation in humidity had little influence. The larvae were found to prefer hairy areas of the body for attachment, and they did not attach at the hairless and exposed areas. The engorged females were found to drop off quickly when green grass was spread on the floor of the experimental animal’s shed. The life-cycle patter could be summarised as: Pre-oviposition : 1 to 6 days Oviposition : 5 to 9 days Incubation period : 16 to 30 days Larval fasting : 2 to 5 days Larval feeding : 4 to 7 days Larval moulting : 8th to 12th day of infection Nymphal feeding : 3 to 6 days Moulting of Nymph : 15 to 19th day of infection Adult feeding : 5 to 10 days Detatchment of female : From 20th day of infection onwards Four organophosphorous compounds viz. Malathion, Fenitrothion, Dichlorvos and Phosalone were tested for their action on ticks. The ovicidal and larvicidal actions and the lethal effects on nymphas and engorged females of B. annulatus, R sanguinius and H. bispinosa were studied in the laboratory. Cythion (malathion 50%) 0.5 to 1%, Sumithion (Fenitrothion 50 %) 0.5 to 1%, Dichlorvos (Nuvan) 0.1 to 0.2%, and Zolone (Phosalone 35 %) 0.2 to 0.3% were found effective at different degrees. The efficacy was directly proportional to the concentration of compound and the duration of treatment. Phosalone showed maximum efficacy followed by Dichlorvos. In field trials, all the four compounds gave satisfactory results. But phosalone showed maximum efficacy and least toxicity to animals. Nuvan was also effective but was the most toxic among the four compounds. Thus the acaricide of choice for routine use in Kerala was determined to be Phosalone (35%) at a concentration of 0.3% to be used as a spray or wash.ThesisItem Open Access Pathology of the reproductive organs in experimental hypothyroidism in goats(Department of Pathology, College of Veterinary and Animal Sciences, Mannuthy, 1982) Nemali Mohan, Reddy; KAU; Rajan, AA survey study was conducted to assess the role of hypothyroidism in the etiology of reproductive disorders in goats. Lowered functional activity of the thyroid was associated with postpartum anoestrum, repeat breeding and delayed puberty. An experimental model of controlled hypothyroid state was induced in goats, using different dose regimes of thiourea with the objective of studying the sequence of physiopathological changes in hypothyroidism and its influence on reproduction. Clinically healthy young and adult cross-bred goats of both sexes were employed for the study. The animals were divided into control, Treatment I (T1) and Treatment II (T2) groups. Groups T1 and T2 were administered thiourea orally at the rate of 50 mg/kg and 100 mg/kg body weight respectively. Clinical symptoms and growth rate were studied. Protein bound iodine, total serum protein and serum cholesterol were estimated. Haematological data were collected and the semen characteristics were evaluated. On the 90th day of the experiment both control and experimental animals were sacrificed leaving at least one animal in each group. These animals were maintained without treatment with thiourea for a further period of 90 days and sacrificed. Cross lesions and histopathological changes in tissues were recorded. Weakness, lethargy, depression, reduced feed intake, subcutaneous oedema of varying degree, loss of libido in males and anoestrum in females were the important clinical features observed. There was stunting of growth and apparent reduction in weight of the animals dosed with thiourea. On discontinuation of treatment with thiourea all the clinical signs manifested disappeared and the animals gained weight progressively. There was significantly decrease in the protein bound iodine, and increase in the total serum protein and cholesterol level in all the animals dosed with thiourea. The values reached the normal level on discontinuation of treatment with thiourea. Microcytic hypochronic anaemia was evident in hypothyroid goats. There was improvement in haemogram values on withdrawal of thiourea administration. Reduction in quantity and quality of semen was observed in hypothyroid goats. The semen appeared normal in quality and quantity on discontinuation of thiourea administration. Gelatinisation of subcutaneous fat and hypertrophy and dilation of the left verntricle were the common findings at autopsy. There was significant increase in the relative weight of the thyroid, pituitary and the adrenal gland. Histologically the thyroid glands exhibited varying degree of hyperplasia and hypertrophy. Predominant histological changes in the pituitary was hyperplasia and hypertrophy of basophil cells and degenerative changes in the acidophils. Adrenal gland showed hypertrophy and depletion of fat in the zona fasciculata. On discontinuation of treatment with thiourea all the lesions disappeared. A significant decrease in the relative weight of the testis and epididymis was observed in all the goats dosed with thiourea. Histologically the seminiferous tubules were small and lined by single layer of spermatogonial cells. Some tubules contained degenerated and desquamated cells without any evidence of sperms. The tubules of the epididymis were small in size and the lining cells showed deciliation and desquamation. These degenerative changes were found to be reversible on discontinuation of treatment with thiourea. The accessory sexual glands, the seminal vesioles and the prostate weighed less in hypothyroid goats. Histologically the cells lining the glands were small inactive, vaculated and hyalinised. After discontinuation of administration of thiourea the reparative changes were almost normal. There was significant decrease in the relative weight of the ovary and uterus in all the animals dosed with thiourea. Histologically ovaries were found to be inactive and only few scattered immature follicles were seen. Uterine glands were few and non secretary type. The lining epithelial cells did not show active mitosis. On discontinuation of treatment with thiourea the weight of the ovary and uterus increased and histologically ovaries and uterus were found to be normal. Kids and female goats were more susceptible to the effects of hypothyroidism. The significant pathological changes observed in the reproductive organs have clarified the importance of hypothyroidism in inducing sub-fertility and infertility in goats. The reversible nature of the lesion was also proved.
