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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Studies on regenerative potential of hepatocytic mesenchymal cells in liver degeneration and delineation of their gene expression in canine
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-09) Saini, Rashmi; Jadon, N.S.
    Twenty four dogs of either sex naturally suffering from hepatic dysfunction were used in this study. The animals were randomly divided into four groups administered with different drug or drugs combination viz. control (Group A); pepsid-C @ 1ml /10 kg body weight, IM alternatively for fifteen days (Group B); hepatocytic stem cells @ 5×107 cells, intraperitonially animal thrice at an interval of 5 days (Group C) and hepatocytic stem cells @ 5× 107 cells, intraperitonially animal thrice at an interval of 5 days + pepsid-C @ 1ml /10 kg body weight, IM alternatively for fifteen days (Group D). The clinical signs, haematological (Hb, TEC, TLC, DLC, PCV, BT and CT), biochemical (serum T.P, serum albumin, serum total bilirubin, serum glucose, serum urea nitrogen, serum creatinine and serum AST, serum ALT and serum GGT) parameters were studied at 0, 3rd, 6th, 10th, 15th and 20th day by using standard protocol. Radiographic and ultrasonographic changes were studied at 0 and 20th day following treatment. Gene expression of CD44 gene was evaluated via real time PCR. On the basis of parameter observed in this study, it was concluded that the effectiveness of treatment at 15th and 20th day interval was more in the animals treated with combination of hepatocytic stem cells + pepsid-C (Group D) and hepatocytic stem cells (Group C) alone as compared to pepsid-C alone (Group B), as indicated by haematological, biochemical, radiographic, ultrasonographic examination and gene expression of CD44 studies. Hepatocytic stem cells and pepsid-C are safe drugs used in the present study as there was no adverse biochemical and hematological changes during entire period of study. However, the variable changes observed during these periods were purely temporarily and were within normal physiological limits. Ultrasonographic study at day 0 interval of all the animals showed various degree of increased echogenicity, hepatopathy, changes in hepatic symmetric or asymmetric, cholecystitis, acute hepatitis and chronic hepatitis. Variable regenerative changes were seen in rest of the three groups B, C and D at 20th day following the administered of pepsid-C alone, hepatocytic stem cells alone and combination of hepatocytic stem cells + pepsid-C respectively. Abdominal radiograph of all the animals of group A, B, C and D at day 0 interval revealed the morphologic abnormalities in size, shape, position, and radio density of the liver. Gene expression of CD44 associated with regeneration was evident in animals where liver derived hepatocytes were administered and not evident in other group (A and B) while GAPDH, being a housekeeping gene was evident in all groups. Hepatocytic stem cells are necessary for the creation of new cells for growth, development and regeneration. These cells are responsible for the development of new specific cells and also have potential to differentiate into different cell types but are mostly bipotent and are specific for the type of tissue they belong to. These hepatocytic stem cells have better effect on liver function. Thus the combination of hepatocytic stem cells and pepsid-C may be used safely by field veterinarian for the treatment of hepatic dysfunction in canine.
  • ThesisItemOpen Access
    Studies on effects of thiopental sodium with and without dexmedetomidine and its reversal with yohimbine in dogs
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2016-07) Saini, Rashmi; Jadon, N.S.