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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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Subject: Veterinary Surgery and Radiology × Author: Arun Kumar × Start date: 2018 × Type: Thesis × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    Apoptic effects of vincristine sulphate and cisplatin scaffolds on HeLa cell line and their clinical efficacy on canine transmissible venereal tumors
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-06) Arun Kumar; Jadon, N.S.
    The present study was undertaken to evaluate the effects of vincristine sulphate, cisplatin and their scaffolds on canine transmissible venereal tumour in twenty four sexually mature adult dogs affected with naturally occurring canine transmissible venereal tumour (CTVT). The animals were randomly divided into four groups (n=6) and subjected to administration of different oncolytic drugs and drugs scaffolds. The animals of group A were administered vincristine sulphate @ 0.025 mg/kg intravenously once in a week for four consecutive weeks and animals of group B were administered cisplatin @ 2.14 mg/kg intravenously and repeated after 21 days. The animals of group C and D were subjected to the administration of scaffolds of vincristine sulphate @ 0.025 mg/kg intravenously once in a week for four consecutive weeks and scaffolds of cisplatin @ 2.14mg/kg intravenously and repeated after 21 days respectively. Preparation and characterization of hydrogel scaffolds were consisting of FTIR measurements, ultrastructure studies and electrochemical analysis. The oncolytic potential of the different chemotherapeutic agent (vincristine sulphate, cisplatin and their scaffolds) was evaluated on the basis of physical and cytological parameters, histopathological studies, haemato-biochemical parameters(Hb, PCV, TLC, DLC and platelets, total protein, glucose, BUN, creatinine, ALT, ASTand GGT) and apoptotic effect on HeLa cell line. Genomic DNA from HeLa cells was isolated and subjected to electrophoresis in agarose gel (1.8%) and 1kb DNA ladder. DNA fragments were visualized under a UV trans-illuminator and compared with a standard marker. Lane C showed no fragmented DNA, however, 20 μg/ml vincristine and 20 μg/ml cisplatin showed fragmented DNA in the form of ladder 1 and 3 after 24 h. Vincristine scaffolds and cisplatin scaffolds showed mild DNA fragment in lane 2 and 4. On the basis of parameter observed in this study, it is concluded that the early and best regression of the CTVT was observed in the animals treated with vincristine scaffolds. Cisplatin regressed the CTVT masses upto some extent; however, cisplatin scaffolds are moderately effective when it is used in appropriate dose. Vincristine alone is effective drug for the treatment of CTVT even in metastatic conditions, however the vincristine scaffolds are more effective as it has early regression of tumour as compare to vincristine alone. This may be due to decreasing the side effects caused in healthy cells. These vincristine scaffolds may be used safely by field veterinarian for the treatment of TVT in canines.