Loading...
Govind Ballabh Pant University of Agriculture and Technology, Pantnagar
After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960.
The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.
Browse
5 results
Search Results
Now showing 1 - 5 of 5
ThesisItem Open Access Evaluation of haemato-biochemical profile and anti-osteoporotic potential of Moringa oleifera in rats(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-03) Rawat, Parul; Ahmed, A.H.The present study was carried out to evaluate haemato-biochemical profile and antiosteoporotic potential of Moringa oleifera in combination with prednisolone induced osteopororsis in rats. Osteopororsis was induced in rats by administration of prednisolone @ 1mg/ kg, bwt, I.P, daily for 28 days under aseptic conditions. Rats were divided in 6 groups of six animals each. Group I served as control, group II and group III were administered aqueous extract of Moringa oleifera (MOAE) @ 200mg/kg b. wt and 500mg/kg b.wt repectively. In group IV and V aqueous extract of Moringa oleifera (MOAE) @ 200mg/kg b. wt and 500mg/kg b.wt with prednisolone @ 1mg/kg b wt and in group VI prednisolone was administered @ 1mg/kg b wt. daily for 28 days. The antiosteoporotic potential was measured by determining bone histomorphometry by X-ray radiography of femur of rats. Osteoporotic biomarkers were recorded by determining alkaline phosphatase and serum calcium. Osteoporotic biomarkers such as ALP and calcium were reduced after treatment with prednisolone. Effect on hepatorenal function was assessed by determining effect on AST, creatinine and BUN level in serum. Treatment with MOAE-1 and MOAE-2 with prednisolone treated rats restored the blood urea nitrogen level and creatinine level. There was signinficant (P<0.05) alteration in body weight, femur weight and radiographic examination which indicated the induction of osteoporosis after 28 days in rats.. In groups treated with MOAE-1 and MOAE-2 with prednisolone showed improvement in level of calcium as compared to control after 14th and 28th day of treatment. In prednisolone treated group dislocation of femur head from pelvic girdle and fracture in mid shaft of femur were observed , which conforms osteoporosis in prednisolone treated group. osteoporosis very often manifests as a bone fracture. Femoral fractures are the most feared complication of osteoporosis. Prednisolone altered hematological parameters like Hb, PCV, TLC, TEC and DLC , effect was ameliorated by treatment with aqueous extract of Moringa oleifera @ 200 and 500 mg/kg b.wt for 28 days. Histopathological changes in liver, kidney and spleen were observed in prednisolone treated groups , and groups including prednisolone with MOAE-1 and MOAE-2. Thus, it can be concluded from present study that the aqueous extract of Moringa oleifera has antiosteoporortic potential against prednisolone induced osteoporosisThesisItem Open Access Immunopharmacological evaluation of Rhododendron arboreum in rats(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-08) Singh, Vaibhav; Singh, S.P.The present study was carried out to investigate the phytoconstituents, antioxidant and antiinflammatory potential and evaluate immunopharmacological potential of hydroethanolic extract of leaves of Rhododendron arboreum (RAHE) following oral administration @ 100 mg/kg b wt, in against cyclophosphamide @ 100 mg/kg b wt, po at 7th and 14th day, induced toxic effects in 30 days study in rats. The phytochemical analysis of plant extract revealed 9.5 % yield and presence of flavonoids, anthraquinones, tannins, sterols, reducing sugars, resins, and proteins. In vitro study revealed antioxidant potential determined by DPPH, ABTS and nitric oxide synthetase activity. and in vivo antiinflammatory study revealed antiinflammatory potential measured by in vitro inhibition of albumin denaturation, antiproteinase activity and in vivo reduction in paw edema induced by Freund’s adjuvant and formalin in rats. To evaluate immunopharmacological properties, twenty-four 6 months Sprague Dawley rats weighing 150-160 gm, were divided into 4 groups of 6 rats each. Group 1 served as control. Group 2 served as therapeutic treatment group and was administered cyclophosphamide @ 100 mg/kg b wt. on 7th and 14th day and RAHE @ 100 mg/kg b wt. from 16th-30th day. Group 3 with cyclophosphamide @ 100 mg/kg b wt. on 7th and 14th day and levamisole @ 50 mg/kg b to 30th b wt, SC. Group 4 served as prophylactic group with cyclophosphamide @ 100 mg/kg b wt. on 7th and 14th day and RAHE @ 100 mg/kg b wt, po, from 1st to 30th days in rats. No abnormal clinical signs and mortality were observed in all the groups throughout the study. Cyclophosphamide caused significant (P<0.05) decrease in Hb, PCV, TEC, TLC, DLC, MCV, MCH and MCHC levels which were ameliorated by RAHE treatment. There was a significant (P<0.05) reduction in the level of total protein, albumin, globulin and A:G ratio in cyclophosphamide treated groups 2 which were ameliorated by oral administration of RAHE in group 4. Significant (P<0.05) increase in the levels of ALT, AST, ALP, LDH, creatinine, triglycerides, cholesterol and bilirubin indicated hepatotoxic effects and BUN and creatinine levels indicated cyclophosphamide induced nephrotoxic effects in group 2 which were ameliorated by treatment with RAHE after 30 days in rats of group 4. A significant (P<0.05) decrease in levels of RBC and tissue GSH, catalase and SOD levels and a significant (P<0.05) increase in LPO levels in cyclophosphamide treated rats of group 2 indicated oxidative stress which was reversed towards normalcy by treatment with RAHE for 30 days in group 4. Cyclophosphamide induced immunosuppression as evident by reduction in HA titre, phagocytic index, neutrophil adhesion test, DTH response and total immunoglobulins in group 2, however, RAHE treated group 4 revealed significant (P<0.05) improvement in these parameters after 30 days indicating immunomodulatory properties of RAHE. On pathological examination, there were no apparent changes in the shape and size and any type of lesions on the visceral organs such as liver, spleen, heart, kidney, lungs and intestine. On histopathological examination, central vein congestion, dilatation of sinusoidal space, degeneration and necrosis of hepatocyte in liver, hemosiderosis and hyperplasia of the white pulp in spleen, intertubular hemorrhage, mononuclear cell infiltration and necrosis of the tubular epithelium in kidneys, emphysema and thickening of the interstitium with congestion in lungs were evident in group 2, however, these changes were either of mild degree or were absent in RAHE treated rats of group 4. It is concluded from the study that RAHE @ 100 mg/kg b wt, orally for 30 days revealed ameliorative effect against cyclophosphamide @ 100 mg/kg b wt, po at 7th and 14th day induced haemotoxic, hepatpotoxic, nephrotoxic, oxidative stress and immunosuppressive effects in 30 day study in rats. Ameliorative effects of RAHE was more potent by prophylactic than therapeutic treatment.ThesisItem Open Access Evaluation of hepatoprotective and antioxidant potential of Platycladus orientalis in paracetamol induced hepatotoxicity in rats(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-07) Saklani, Samiksha; Singh, S.P.Hepatotoxicity refers to chemical or drug driven hepatic injury in man and animals. The aim of this study was to evaluate the hepatoprotective and antioxidant potential of hydroethanolic extract of (HEPO) Platycladus orientalis following oral administration @ 200mg/kg and 400mg/kg b.wt. in paracetamol @500mg/kg b.wt treated rats and also comparing its efficacy with standard hepatoprotective drug silymarin @ 100mg/kg b.wt for 21days. The phytochemical analysis of leaf extract of hydroethanolic extract of Platycladus orientalis revealed 11% yield and the presence of alkaloids, flavonoids, phenolic compounds, sugars, glycosides, proteins and saponins. Thirty rats were equally divided into 5 groups with 6 rats in each group. Group I served as control, group II rats were administered with PCM, group III with PCM @ 500mg/ kg b. wt. plus silymarin @100 mg/kg, group IV with PCM @ 500mg/ kg b. wt. plus HEPO @ 200mg/kg and group V with PCM @ 500mg/ kg b wt. plus HEPO @ 400mg/kg b. wt. for 21 days . There was no noticeable change in the appearance, behaviour and body weight in rats of all groups after 21 days. Paracetamol caused significant (P<0.5) reduction in Hb, PCV, TEC and TLC as compared to control group. HEPO group IV and group V showed significant (P<0.5) increase in these parameters in dose dependent manner. A significant (P<0.05) decline in total protein, albumin and globulin was observed in group II as compared to control. HEPO treated groups IV and V showed significant (P<0.05) amelioration in the level of total proteins as compared to group II and at par with silymarin. A significant (P<0.05) increase in values of triglycerides, cholesterol, creatinine, BUN, AST, ALT, ALP, bilirubin was observed in paracetamol treated group II, which were restored by HEPO towards normal. A significant (P<0.05) decline in RBC and tissue GSH, SOD and catalase activity and a significant (P<0.05) increase in LPO were observed in paracetamol treated group as compared to control. HEPO showed amelioration in dose dependent manner indicating potent antioxidant effect of HEPO following 21 days oral administration in rats. This was also supported by in vitro DPPH and ABST free radical scavenging activity of HEPO. Histopathological changes in paracetamol treated groups were characterized by severe degree of congestion of central vein and sinusoids, severe degeneration and necrosis of hepatocytes. In spleen, severe lymphoid depletion and loss of lymphocytes in area of pariarteriolar lymphoid sheath (PALS) was evident. In heart, fragmentation of muscles fiber bundle and necrosis of cardiomyocytes and in kidney, severe congestion of blood vessel, haemorrhage and fragmentation and complete loss of glomeruli, necrosis of renal tubular epithelial cells were observed in paracetamol treated group which were ameliorated by treatment with HEPO in a dose dependent manner after 21 days in rats. Thus, it is concluded from the present study that hydroethanolic extracts of P. orientalis (HEPO) at daily oral dose @ 200 & 400 mg/ kg b. wt. produced hepatoprotective and antioxidant potential against paracetamol daily oral dose @ 500 mg/kg b. wt. induced hepatotoxicity toxicity after 21 days treatment in rats.ThesisItem Open Access Evaluation of immunomodulatory potential of Cuminum cyminum in rats(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-08) Patwal, Poorna Chandra; Ahmad, A.H.The present study was conducted to analyze the ameliorating potential of Cuminum cyminum against cyclophosphamide induced immunosuppression. The phytochemical analysis of plant extract revealed the presence of alkaloids, flavonoids, phenolic compounds, reducing sugars, glycosides and proteins. Experimental design comprised of eight groups with each group having six rats. Group I served as control, group II was administered with cyclophosphamide @ 100 mg/kg b. wt. orally, in group III levamisole was administered @ 50 mg/kg b.wt. subcutaneously, in group IV both cyclophosphamide and levamisole were administered, group V and group VI were administered with hydroethanolic extract of Cuminum cyminum (CCHE) @200 and 400 mg/kg b.wt. orally, respectively and in group VII and group VIII, CCHE was administered @ 200 and 400 mg/kg b.wt. orally with cyclophosphamide @ 100mg/kg b.wt. on 9th and 16th day of study, respectively for a period of 28 days. Significant (P<0.05) decrease in body weight and organ weight of cyclophosphamide treated rats was seen. However, body weight was restored in group VII and VIII. Cyclophosphamide exposure showed a significant (P<0.05) reduction in Hb, PCV, TEC, TLC and DLC as compared to other groups. A significant (P<0.05) decline in total protein, albumin, globulin and A: G ratio was observed in group II as compared to control. CCHE treated groups V, VI, VII and VIII showed significant (P<0.05) amelioration in the level of total proteins as compared to group II and at par with normal values in control showing ameliorative potential of CCHE. A significant (P<0.05) increase in cholesterol, creatinine, BUN, AST, ALT and ALP was observed in cyclophosphamide treated group II, which were restored by CCHE towards normal indicating amelioration of these parameters by CCHE. A significant (P<0.05) decrease in HA titre, total Ig level, DTH reaction, phagocytic index and neutrophil adhesion was observed in cyclophosphamide treated group II, whereas, treatment with CCHE restored these parameters towards normal values in a dose dependent manner indicating immune stimulation by CCHE. Histopathological changes in liver were characterized by severe congestion of blood vessels and severe sinusoidal congestion leading to loss of sinusoidal spaces, accumulation of mononuclear cells around many congested blood vessels, severe degeneration of hepatocytes throughout the parenchyma in liver. In kidney severe congestion of large blood vessels and interstitial hemorrhages, vacuolation of glomeruli of the renal tubular epithelial cells and infiltration of mononuclear cells was observed. These effects were ameliorated by treatment with CCHE in a dose dependent manner after 28 days in rats. Thus, it can be concluded from the present study that hydroethanolic extracts of Cuminum cyminum has immunostimulant potential against cyclophosphamide induced toxicity.ThesisItem Open Access Evaluation of immunomodulatory activity of Trianthema portulacastrum Linn. in rats(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-06) Aswathy, P.U.; Ahmed, A.H.The present study was carried out to investigate the immunomodulatory activity of Trianthema portulacastrum Linn. in combating cyclophosphamide induced immunosuppression. The qualitative phytochemical analysis of plant extract revealed the presence of flavonoids, saponins, glycosides, phenolic compounds, alkaloids, reducing sugars and proteins. The quantitative phytochemical analysis of plant extract revealed a total phenolic content of 84.33±4.70 mg gallic acid equivalent per g of extract and the total flavonoid content was found to be 31.60±2.90 mg rutin equivalent per g of extract.The experimental design comprised of eight groups with each group having six rats. Group I served as control, group II rats were administered cyclophosphamide @100 mg/kg b. wt. p.o on 9th and 16th day of treatment, in group III levamisole was administered @ 50 mg/kg b wt. sc, in group IV both cyclophosphamide and levamisole, group V was administered hydroethanolic extract of Trianthema portulacastrum (TPHE)@ 200 mg/kg b.wt, group VI was administered TPHE @ 200 mg/kg b.wt along with cyclophosphamide @ 100 mg/kg b. wt (on 9th and 16th day @ 100 mg/kg body weight p.o, group VII was administered with TPHE @ 400 mg/kg body weight p.o and group VIII was administered with TPHE @ 400 mg/kg body weight along with cyclophosphamide for 28 days. Cyclophosphamide produced significant (p<0.05) reduction in body weight and organ weights which were restored to normal by treatment with TPHE in groups VI and VIII. Cyclophosphamide administration caused significant (p<0.05) reduction in Hb, TEC, TLC, Platelet, DLC and PCV as compared to other groups. A significant (p<0.05) decrease in total protein, albumin, globulin and A: G was observed in group II as compared to control. TPHE treated groups V, VI, VII and VIII showed significant (p<0.05) amelioration in the cyclophosphamide induced reduction of total proteins as compared to group II. Cyclophosphamide showed a significant (p<0.05) increase in triglycerides, cholesterol, creatinine, BUN, AST, ALT and ALP compared to other groups which were restored by TPHE towards normal. Cyclophosphamide produced a significant (p<0.05) decrease in HA titre, DTH reaction, neutrophil adhesion, phagocytic index, total Ig level, and immunoglobulin (IgM and IgG) estimation but treatment with TPHE restored these parameters towards normal values in a dose dependent manner indicating its immunostimulatory activity. Histopathological changes in spleen were characterized by loss of white pulp mainly in the peripheral region, degenerative changes both in red pulp and white pulp making its differentiation difficult and accumulation of macrophages and haemosiderin deposits. In liver, necrotized hepatocytes , karyolysis and vacuolation of cytoplasm, lack of proper lobulation pattern, bile duct hyperplasia and accumulation of neutrophils and lymphocytes. Lung of cyclophosphamide treated rats showed emphysema, interstitial pneumonia with infiltration of lymphocytes and thickening of interalveolar septa which were ameliorated by treatment with TPHE in a dose dependent manner after 28 days of treatment in rats. Thus, it can be concluded from the present study that hydroethanolic extracts of Trianthema portulacastrum has immunostimulatory activity against cyclophosphamide induced immunosuppression.