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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Clinocopathological studies on nanosilver administered Wistar rats
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2021-12) Neeraj Kumar; Batra, Munish
    The present study investigated the pathological effects of nanosilver at NOAEL dose in Wistar rats for a period of 90 days. A total of 35 rats of 6 weeks age were divided randomly into group 1 (control group) and group II (treatment group). Group 1 rats were administered nanosilver orally at NOAEL dose (30 mg/kg). In group II rats, most of rats were dull and lethargic and there was decrease in feed intake. A significant time dependent decrease in body weight. Blood parameters shows decrease in packed cell volume (PCV), haemoglobin (Hb), and total erythrocyte count (TEC). Morphology of erythrocytes is normocytic hypochromic anaemia with increase central pallor. Erythrocytic indices shows significant changes including MCH and MCH values were significant increased while MCHC shows nonsignificant changes in treated rats as compared to control rats. Other blood parameters like total leucocyte count (TLC) and total thrombocyte count (TTC) shows significant increase in value in treated group as compared to control. In differential leucocyte count, lymphocyte count was significantly decreased but neutrophil showed significant increase in value while eosinophils, monocytes and basophils showed nonsignificant variation in both groups throughout experiment. Other blood parameters like absolute neutrophil count (ANC) showed significant increase in value while absolute lymphocyte (ALC) was significantly decrease in treated group as compared to control. In biochemical profile there was significant increase in serum aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), and cholesterol while other parameters like total serum protein, serum gamma globulin, serum albumin, serum globulin, and serum glucose showed decrease in value in treated group as compared to control. Other biochemical parameters like serum calcium and serum phosphorus showed nonsignificant changes in both groups throughout experiment. Grossly group I rats shows non-significant changes while group II rats show red patches in liver, red discoloration in lungs and mild congestion in heart. Histopathologically, no significant lesions could be in any organ of group I rats while in group II rats revealed congestion, thrombus formation, and degeneration of hepatocytes in liver, thickening of interalvular wall, emphysema, congestion and increase number of mononuclear cells in lungs. kidneys revealed the congestion of glomerular capillaries, interstitial haemorrhage, and coagulative necrosis. Heart of group II rats revealed congestion, necrosis, and mild enema in cardiac muscle fibres. Other organs like , spleen, uterus and testis showed non-significant changes. Collectively, these observations indicated that nanosilver at NOAEL dose has toxic effects on heath including serum biochemicals and tissue changes. The observations regarding pathomorphological alterations indicates that liver, kidneys, and lungs, were the most affected organs in nanosilver toxicity. Mild effect on heart was also observed. Collectively our results suggest that nanosilver have toxic effects even at NOAEL dose on the repeated exposure. The use of silver nanoparticles should be used restricted or avoided.