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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Clinicopathological alterations induced by the combined effect of iron and aluminium nanoparticles in wistar rats
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2020-10) Kohli, Nisha; Agarwal, Seema
    The present experiment was designed to know the clinicopathological alterations caused by the combined effect of iron and aluminium nanoparticles in Wistar rats in a repeated dose study for 90 days. The experimental design consisted of 35 Wistar rats randomly divided into 2 groups; GI as control group with 20 rats and GII as treatment group with 15 rats from day 0 and till 90 DPT. Control group was provided with standard feed and RO water and in treated group along with standard feed and RO water, nano-iron oxide and nano-aluminium oxide mixed in distilled water was also gavazed at the dose half of the NOAEL dose viz. 15mg/kg/BW and 3mg/kg/BW respectively. Upon routine examination, rats did not show any abnormal behaviour and clinical sign. However, there was decrease in mean body weight in the treated group. Haematological parameters showed decrease in total erythrocyte count (TEC), packed cell volume (PCV), total leucocyte count (TLC) and absolute lymphocyte count (ALC) and decrease in haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) in treated group as compared to control group. Biochemical examination demonstrated increase in aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and BUN whereas there was decrease in serum total protein, serum albumin, serum globulin and serum gamma globulin in treated group as compared to the control group. Immunological parameters demonstrated decrease in HI titer, ELISA, B and T lymphocyte blastogenesis. Histopathology in nano-iron and nano-aluminium treated rats. Liver showed degenerative and necrotic changes in the hepatic cells with hemorrhages, congestion and infiltration of mononuclear cells. Lung revealed emphysema, atelectasis and increase in the thickening of the interalveolar septa alongwith mononuclear cell infilteration. Kidney shows lesions of glomerulonephritis. Intestine revealed increase in the number of the goblet cells, along with the shortening, blunting and fusion of villi. Spleen showed congestion, necrosis and depletion of the white pulp area. Heart muscles showed degeneration and necrosis of muscle fibres. Brain revealed neuronal degeneration, gliosis and perivascular cuffing. Thus the present study suggest that nano iron and nano aluminium at the rate of half of their NOAEL dose i.e. 15mg/kg BW and 3 mg/kg BW when gavaged for 90 days causes pathological alterations in the exposed rats. Though some of the results were not statistically significant but findings from the present investigation confirm the pathological changes on various parts of the body that leads to immunopathy, hepatopathy, nephropathy and neuropathy which may result into the down regulation of immunity. Also, histopathological studies suggested that accumulation of these nanoparticles in body induces structural alterations in the various organs. Further studies, should be carried out in different animal models using varied doses and increased duration of nano iron and nano aluminium to exactly find out the pathological and immunosuppressive properties of these nanoparticles.