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Kerala Veterinary and Animal Sciences University, Wayanad

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20051
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Subject: Veterinary Physiology × Author: BALAJI, S. × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    HYPOGLYCAEMIC EFFICACY OF SCOPARIA DUiaS AND COSTUS SPECIES IN ALBINO RATS
    (College of Veterinary and Animal Sciences, Mannuthy., 2005) BALAJI, S.; Dr.K.P.Sreekuniar
    The prcscnl study was undertaken to assess the h_\poglyeaeiTiie aetivitv of aqueous and aleoholie extraet of Scoparia dulcis and Costus pictiis 'w 5()0mg/kg bod\ weight orally in alloxan indueed diabetic rats and also in combination and to compare their erficacy with a standard oral hypoglycaemic drug, glibenclamide. 1 he experiment v\as conducted in seventy-two male Sprague-Dawle> rats for a period of bOdays. with eight animals in each grimp ((iroup 1 to IX), (iroup 1 ser\ed as normal control and Group 11 is diabetic contrcd, Aquecuis leaf extract of Scoparia dulcis and Cosliis picliis 'd) 500 mg/kg b.w orally were giv en to Group 111 and IV, respectively for 60 days. Group V and VI were given alcoholic leaf extract of Scoparia dulcis and Costus picius fa) 500 mg/kg b.w orally. respccli\cl\ for 60 dav s. Group VII and Vlll received combination of aqueous and alcoholic leaf extract of Scoparia dulcis and Costus pictus a 500 mg/kg b.w oralK. respectively for 60 days. Glibenclamide @ 0.5mg/animal/day was fed to (iroup IX. Body weight was recorded and RBC, WBC, total haemoglobin and glvcosylated haemoglobin content were estimated on zero day, 7"\ 14''\ 28''\ 56"'. and 6()"' day of the experiment. Plasma glucose, plasma total lipids. plasma total cholesterol, trigUcerides, plasma MDL-C, plasma total protein, plasma albumin, plasma Al/f and AST were also estimated. The liver glvcogen and plasma ctppcr. iron and zinc content were estimated at the end of the experimental period. Body weight was gradually increased during the experimental period in all treated group except the diabetic control, which showed a significant (psO.OOl ) reduction in bod> weight. The RBC and WBC values did not show any significant change during the entire course of the experiment and maintained a normal lev el. I he total haemoglobin content was increased in the animals treated with combination of alcoholic leaf extract of Scoparia dulcis and Costus pictus by two months of experiment. Glycosylated haemoglobin level also significantlv decreased in all Ihe treatment groups, which is comparable to that of the animals treated with glibenclamide. The animals treated with alcoholic leaf extract ol' Scopariu Jii/cis produced a marked reduction in plasma glucose level, which was higher than the reduction produced by the animals treated with glibenclamide at the end ol the experiment. The plasma total lipids and plasma total cholesterol content w ere markedl) reduced in the animals treated with a combination of alcoholic leaf extract ol Scoparia dulcis and Costus picliis, which is comparable to that pn)duced b\ glibenclamide treated group. The plasma triglyccride. plasma LDl.-C and VI.1)1, C lew el were markedly reduced in the animals treated with alcoholic leal extract ol Scoparia dulcis.. The 111)L-C le\el was increased in ihe animals treated with combination of alcoholic leaf extract oi Scoparia dulcis and C'osius piciiis than the animals treated w ith glibenclamide. 1 he plasma total protein and albumin content was increased in the tinimals treated with aqueous leaf extract o( Costus piclus. I he globulin content and A.'C, ratio was increased in the animals treated with a combination of aqueous leal extract oi'Scoparia dulcis and Coslus piclus. The liver en/ymes such as ALT and AS f were reduced in the animals treated with alcoholic leaf extract of Scoparia dulcis. The liver glycogen content was increased in animals treated with alcoholic leal extract ol Coslus piclus. which is comparable to that ol animals treated with alcoholic leal extiiiet ol Scoparia dulcis. 1 he plasma copper and iron content did not show any change but the /inc content was increased in all the treated groups than the diabetic control animals.